Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways
Coronavirus disease (COVID-19) is caused by SARS-CoV-2 virus, which can result in serious respiratory illnesses such as pneumonia leading to respiratory failure. It was first reported in Wuhan, Hubei, China, in December 2019 and rapidly spread globally, becoming a pandemic in March 2020. Among comor...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8896536 |
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| author | Ersilia Nigro Fabio Perrotta Rita Polito Vito D’Agnano Filippo Scialò Andrea Bianco Aurora Daniele |
| author_facet | Ersilia Nigro Fabio Perrotta Rita Polito Vito D’Agnano Filippo Scialò Andrea Bianco Aurora Daniele |
| author_sort | Ersilia Nigro |
| collection | DOAJ |
| description | Coronavirus disease (COVID-19) is caused by SARS-CoV-2 virus, which can result in serious respiratory illnesses such as pneumonia leading to respiratory failure. It was first reported in Wuhan, Hubei, China, in December 2019 and rapidly spread globally, becoming a pandemic in March 2020. Among comorbidities observed in SARS-CoV-2 positive patients, hypertension (68.3%) and type 2-diabetes (30.1%) are the most frequent conditions. Although symptoms are highly heterogeneous (ranging from absence of symptoms to severe acute respiratory failure), patients with metabolic-associated diseases often experience worse COVID-19 outcomes. This review investigates the association between metabolic disorders and COVID-19 severity, exploring the molecular mechanisms potentially underlying this relationship and those that are responsible for more severe COVID-19 outcomes. In addition, the role of the main biological processes that may connect metabolic alterations to SARS-CoV-2 infection such as hyperglycemia, immune system deregulation, ACE-2 receptor modulation, and inflammatory response is described. The impact of metabolic disorders on the prognosis of COVID-19 has major implications in public health especially for countries affected by a high incidence of metabolic diseases. |
| format | Article |
| id | doaj-art-90db45b13a3541f492cea674631de22a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-90db45b13a3541f492cea674631de22a2025-02-03T01:08:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/88965368896536Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular PathwaysErsilia Nigro0Fabio Perrotta1Rita Polito2Vito D’Agnano3Filippo Scialò4Andrea Bianco5Aurora Daniele6Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Università Degli Studi Della Campania “Luigi Vanvitelli”, Via G. Vivaldi 42, Caserta 81100, ItalyDipartimento di Medicina e Scienze Della Salute “V. Tiberio”, Università Del Molise, Campobasso 86100, ItalyCEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, Napoli 80145, ItalyDipartimento di Scienze Mediche Traslazionali e Chirurgiche, Università Della Campania “L. Vanvitelli”, Napoli 80131, ItalyDipartimento di Scienze Mediche Traslazionali e Chirurgiche, Università Della Campania “L. Vanvitelli”, Napoli 80131, ItalyDipartimento di Scienze Mediche Traslazionali e Chirurgiche, Università Della Campania “L. Vanvitelli”, Napoli 80131, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Università Degli Studi Della Campania “Luigi Vanvitelli”, Via G. Vivaldi 42, Caserta 81100, ItalyCoronavirus disease (COVID-19) is caused by SARS-CoV-2 virus, which can result in serious respiratory illnesses such as pneumonia leading to respiratory failure. It was first reported in Wuhan, Hubei, China, in December 2019 and rapidly spread globally, becoming a pandemic in March 2020. Among comorbidities observed in SARS-CoV-2 positive patients, hypertension (68.3%) and type 2-diabetes (30.1%) are the most frequent conditions. Although symptoms are highly heterogeneous (ranging from absence of symptoms to severe acute respiratory failure), patients with metabolic-associated diseases often experience worse COVID-19 outcomes. This review investigates the association between metabolic disorders and COVID-19 severity, exploring the molecular mechanisms potentially underlying this relationship and those that are responsible for more severe COVID-19 outcomes. In addition, the role of the main biological processes that may connect metabolic alterations to SARS-CoV-2 infection such as hyperglycemia, immune system deregulation, ACE-2 receptor modulation, and inflammatory response is described. The impact of metabolic disorders on the prognosis of COVID-19 has major implications in public health especially for countries affected by a high incidence of metabolic diseases.http://dx.doi.org/10.1155/2020/8896536 |
| spellingShingle | Ersilia Nigro Fabio Perrotta Rita Polito Vito D’Agnano Filippo Scialò Andrea Bianco Aurora Daniele Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways International Journal of Endocrinology |
| title | Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways |
| title_full | Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways |
| title_fullStr | Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways |
| title_full_unstemmed | Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways |
| title_short | Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways |
| title_sort | metabolic perturbations and severe covid 19 disease implication of molecular pathways |
| url | http://dx.doi.org/10.1155/2020/8896536 |
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