Advances research in porcine enteric coronavirus therapies and antiviral drugs
The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause si...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Veterinary Quarterly |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01652176.2024.2421299 |
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| author | Jixiang Liang Weihang Xu Xiaoming Pan Shiyun Han Linwei Zhang Hao Wen Mingyue Ding Wanpo Zhang Dapeng Peng |
| author_facet | Jixiang Liang Weihang Xu Xiaoming Pan Shiyun Han Linwei Zhang Hao Wen Mingyue Ding Wanpo Zhang Dapeng Peng |
| author_sort | Jixiang Liang |
| collection | DOAJ |
| description | The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause similar clinical characteristics including weight loss, sleepiness, vomiting, anorexia and fatal diarrhea in neonatal piglets, resulting in significant economic losses to the global pig industry. Although many studies on drugs for treating and combating PECs have been issued. There are still no specific drug targeting PECs and used in clinical production. Therefore, it is necessary to sort out and summarize the research on the treatment and anti PECs drugs, and further development of low toxicity and high efficiency drugs is needed. Here, we review the latest progress of anti PECs drugs, focus on the mechanism of anti PECs reaction of drug components, and try to clarify new strategies for effective control and elimination of PECs. These comprehensive and profound insights will help to further investigate, prevent and control the transmission of PECs infection. |
| format | Article |
| id | doaj-art-90daa24fcbf54185a3f390550f07686b |
| institution | OA Journals |
| issn | 0165-2176 1875-5941 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj-art-90daa24fcbf54185a3f390550f07686b2025-08-20T02:19:51ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412024-12-0144114910.1080/01652176.2024.2421299Advances research in porcine enteric coronavirus therapies and antiviral drugsJixiang Liang0Weihang Xu1Xiaoming Pan2Shiyun Han3Linwei Zhang4Hao Wen5Mingyue Ding6Wanpo Zhang7Dapeng Peng8College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaCollege of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of ChinaThe porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause similar clinical characteristics including weight loss, sleepiness, vomiting, anorexia and fatal diarrhea in neonatal piglets, resulting in significant economic losses to the global pig industry. Although many studies on drugs for treating and combating PECs have been issued. There are still no specific drug targeting PECs and used in clinical production. Therefore, it is necessary to sort out and summarize the research on the treatment and anti PECs drugs, and further development of low toxicity and high efficiency drugs is needed. Here, we review the latest progress of anti PECs drugs, focus on the mechanism of anti PECs reaction of drug components, and try to clarify new strategies for effective control and elimination of PECs. These comprehensive and profound insights will help to further investigate, prevent and control the transmission of PECs infection.https://www.tandfonline.com/doi/10.1080/01652176.2024.2421299PEDVTGEVSADS-CoVPDCoVtherapyantiviral drugs |
| spellingShingle | Jixiang Liang Weihang Xu Xiaoming Pan Shiyun Han Linwei Zhang Hao Wen Mingyue Ding Wanpo Zhang Dapeng Peng Advances research in porcine enteric coronavirus therapies and antiviral drugs Veterinary Quarterly PEDV TGEV SADS-CoV PDCoV therapy antiviral drugs |
| title | Advances research in porcine enteric coronavirus therapies and antiviral drugs |
| title_full | Advances research in porcine enteric coronavirus therapies and antiviral drugs |
| title_fullStr | Advances research in porcine enteric coronavirus therapies and antiviral drugs |
| title_full_unstemmed | Advances research in porcine enteric coronavirus therapies and antiviral drugs |
| title_short | Advances research in porcine enteric coronavirus therapies and antiviral drugs |
| title_sort | advances research in porcine enteric coronavirus therapies and antiviral drugs |
| topic | PEDV TGEV SADS-CoV PDCoV therapy antiviral drugs |
| url | https://www.tandfonline.com/doi/10.1080/01652176.2024.2421299 |
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