Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity center
Abstract Introduction Gastrointestinal infections represent a worldwide public health problem. In Colombia, the incidence reaches 21.4 cases per 1,000 inhabitants. Given the limitations of traditional diagnostic methods in terms of sensitivity and specificity, the gastrointestinal panel (GIP) has em...
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BMC
2025-03-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03693-6 |
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| author | Jorge Andrés Salazar-Arenas Leidy Johanna Hurtado-Bermúdez Edgar David Salazar-Cardona Nelson Enrique Rojas-Rojas Juan Felipe Cubides-Martinez Juan David Toro-Palma Valeria Zúñiga-Restrepo Carlos Arturo Rojas-Rodríguez |
| author_facet | Jorge Andrés Salazar-Arenas Leidy Johanna Hurtado-Bermúdez Edgar David Salazar-Cardona Nelson Enrique Rojas-Rojas Juan Felipe Cubides-Martinez Juan David Toro-Palma Valeria Zúñiga-Restrepo Carlos Arturo Rojas-Rodríguez |
| author_sort | Jorge Andrés Salazar-Arenas |
| collection | DOAJ |
| description | Abstract Introduction Gastrointestinal infections represent a worldwide public health problem. In Colombia, the incidence reaches 21.4 cases per 1,000 inhabitants. Given the limitations of traditional diagnostic methods in terms of sensitivity and specificity, the gastrointestinal panel (GIP) has emerged as a promising tool, allowing rapid detection of 22 pathogens. This study aimed to describe the clinical and microbiological characteristics of immunosuppressed and immunocompetent adult patients with diarrhea and the influence of the gastrointestinal panel in their treatment in a high-complexity hospital in Colombia. Materials and methods A cross-sectional observational study was carried out including 350 adult patients treated at the Fundación Valle del Lili hospital between 2021 and 2022. Demographic and clinical variables, GIP findings and treatment were analyzed by univariate and bivariate analysis. We compare immunocompromised and immunocompetent adult patients using Chi-square tests, Fisher’s F test for qualitative variables, Student’s t-test, and the Mann-Whitney U test for quantitative variables. A significance level of 5% was applied to demonstrate the significance of the variables in all the tests used. Results The results showed that 52% were men, with an average age of 52 years. 72.0% presented acute diarrhea, being inflammatory in 60.1%. 39.1% of the patients were immunosuppressed, mainly transplant recipients (31.3%). 53% of the GIPs were positive, with up to 5 pathogens per sample. Bacteria were detected in 80%, viruses in 14.4%, and parasites in 5.5%. The most frequent bacteria were enteropathogenic E. coli (43.0%), enteroaggregative E. coli (18.6%), and C. difficile (17.4%). Norovirus was the predominant virus (67.7%) and Cryptosporidium the most common parasite (41.7%). A higher frequency of Vibrio spp. was observed in non-immunosuppressed patients (p = 0.004) and of enterotoxigenic E. coli in immunosuppressed patients. 41.0% of patients received antibiotic/antiviral therapy, 83% empirically. GIP influenced the treatment of 56.7% of patients, with a 90.0% recovery rate. Conclusion This study confirms that GIP is a valuable diagnostic tool in the management of adult patients with diarrheal disease, particularly in immunocompromised patients. In our setting it is still a costly and difficult to access test, which makes it necessary to standardize the indications for its application. Future studies could evaluate its cost-effectiveness in our context. |
| format | Article |
| id | doaj-art-90da35652fcb4b5d92d1a995c2e115aa |
| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-90da35652fcb4b5d92d1a995c2e115aa2025-08-20T03:06:00ZengBMCBMC Gastroenterology1471-230X2025-03-012511710.1186/s12876-025-03693-6Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity centerJorge Andrés Salazar-Arenas0Leidy Johanna Hurtado-Bermúdez1Edgar David Salazar-Cardona2Nelson Enrique Rojas-Rojas3Juan Felipe Cubides-Martinez4Juan David Toro-Palma5Valeria Zúñiga-Restrepo6Carlos Arturo Rojas-Rodríguez7Departamento de Medicina Interna, Servicio de Gastroenterología, Fundación Valle del LiliCentro de Investigaciones Clínicas, Fundación Valle del LiliCentro de Investigaciones Clínicas, Fundación Valle del LiliFacultad de Ciencias de la Salud, Universidad IcesiFacultad de Ciencias de la Salud, Universidad IcesiFacultad de Ciencias de la Salud, Universidad IcesiFacultad de Ciencias de la Salud, Universidad IcesiDepartamento de Medicina Interna, Servicio de Gastroenterología, Fundación Valle del LiliAbstract Introduction Gastrointestinal infections represent a worldwide public health problem. In Colombia, the incidence reaches 21.4 cases per 1,000 inhabitants. Given the limitations of traditional diagnostic methods in terms of sensitivity and specificity, the gastrointestinal panel (GIP) has emerged as a promising tool, allowing rapid detection of 22 pathogens. This study aimed to describe the clinical and microbiological characteristics of immunosuppressed and immunocompetent adult patients with diarrhea and the influence of the gastrointestinal panel in their treatment in a high-complexity hospital in Colombia. Materials and methods A cross-sectional observational study was carried out including 350 adult patients treated at the Fundación Valle del Lili hospital between 2021 and 2022. Demographic and clinical variables, GIP findings and treatment were analyzed by univariate and bivariate analysis. We compare immunocompromised and immunocompetent adult patients using Chi-square tests, Fisher’s F test for qualitative variables, Student’s t-test, and the Mann-Whitney U test for quantitative variables. A significance level of 5% was applied to demonstrate the significance of the variables in all the tests used. Results The results showed that 52% were men, with an average age of 52 years. 72.0% presented acute diarrhea, being inflammatory in 60.1%. 39.1% of the patients were immunosuppressed, mainly transplant recipients (31.3%). 53% of the GIPs were positive, with up to 5 pathogens per sample. Bacteria were detected in 80%, viruses in 14.4%, and parasites in 5.5%. The most frequent bacteria were enteropathogenic E. coli (43.0%), enteroaggregative E. coli (18.6%), and C. difficile (17.4%). Norovirus was the predominant virus (67.7%) and Cryptosporidium the most common parasite (41.7%). A higher frequency of Vibrio spp. was observed in non-immunosuppressed patients (p = 0.004) and of enterotoxigenic E. coli in immunosuppressed patients. 41.0% of patients received antibiotic/antiviral therapy, 83% empirically. GIP influenced the treatment of 56.7% of patients, with a 90.0% recovery rate. Conclusion This study confirms that GIP is a valuable diagnostic tool in the management of adult patients with diarrheal disease, particularly in immunocompromised patients. In our setting it is still a costly and difficult to access test, which makes it necessary to standardize the indications for its application. Future studies could evaluate its cost-effectiveness in our context.https://doi.org/10.1186/s12876-025-03693-6Gastrointestinal panelDiarrheaMicroorganismsGastrointestinal infections |
| spellingShingle | Jorge Andrés Salazar-Arenas Leidy Johanna Hurtado-Bermúdez Edgar David Salazar-Cardona Nelson Enrique Rojas-Rojas Juan Felipe Cubides-Martinez Juan David Toro-Palma Valeria Zúñiga-Restrepo Carlos Arturo Rojas-Rodríguez Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity center BMC Gastroenterology Gastrointestinal panel Diarrhea Microorganisms Gastrointestinal infections |
| title | Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity center |
| title_full | Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity center |
| title_fullStr | Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity center |
| title_full_unstemmed | Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity center |
| title_short | Clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high-complexity center |
| title_sort | clinical and microbiological profile of patients with diarrhea evaluated using the gastrointestinal panel in a high complexity center |
| topic | Gastrointestinal panel Diarrhea Microorganisms Gastrointestinal infections |
| url | https://doi.org/10.1186/s12876-025-03693-6 |
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