Extracts of Apium graveolens (Celery) attenuate hepato-renal injury induced by chronic administration of gentamicin in mice through activation of Nrf2-antioxidant signaling pathways

Extracts of Apium graveolens (Celery) attenuate hepato-renal injury induced by chronic administration of gentamicin in mice through activation of Nrf2-antioxidant signaling pathways

Objective: This study aimed at investigating the protective effect of extracts from Apium graveolens against gentamicin-induced hepato-renal toxicity.Materials and Methods: The aqueous and hydro-ethanolic extracts of A. graveolens designated respectively as WAG and HAG were tested for their in vitro...

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Main Authors: Arnaud Kouam, Mayelle Mokam, Eleonore Ngounou, Ferdinand Kouoh, Rodrigue Fifen, Kerinyuy Kongnyuy, Elisabeth Zeuko’o, Nembu Nembo, Pascal Dieudonné Djamen, Frédéric Njayou, Paul Moundipa, Emmanuel Asongalem
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2025-07-01
Series:Avicenna Journal of Phytomedicine
Subjects:
apium graveolens
gentamicin-toxicity
mice
liver
kidney
protection
antioxidant
Online Access:https://ajp.mums.ac.ir/article_25338_173f8999b0971d4c26cc916e54ffa50d.pdf
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Summary:Objective: This study aimed at investigating the protective effect of extracts from Apium graveolens against gentamicin-induced hepato-renal toxicity.Materials and Methods: The aqueous and hydro-ethanolic extracts of A. graveolens designated respectively as WAG and HAG were tested for their in vitro antioxidant activities. Then, their cytoprotective effects were assessed against gentamicin-induced cytotoxicity in primary mouse hepatocytes. Finally, mice were administered with gentamicin (20 mg/kg) and co-treated with HAG for 14 days, and histopathology, biochemical and molecular parameters related to gentamicin-induced toxicity were evaluated.Results: HAG exhibited outstanding chemical antioxidant activities and preserved hepatocytes from gentamicin-induced cytotoxicity.  HAG relieved liver and kidney histopathological and biochemical changes, and enhanced the mRNA level of Nrf2 and its target gene HO-1 in gentamicin-intoxicated mice.Conclusion: HAG attenuates hepato-renal injuries induced by 14-days administration of gentamicin in mice through the activation of Nrf2-antioxidant signaling pathways.
ISSN:2228-7930
2228-7949

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