Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations]
Background In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation’s decision to recomme...
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2024-12-01
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| Online Access: | https://wellcomeopenresearch.org/articles/6-120/v4 |
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| author | Mark D. Lyttle Helen Groves Thomas C. Williams Simon B. Drysdale Ian Sinha Xinxue Liu Steve Cunningham Dalia Iskander Abigail Maxwell-Hodkinson Shaun O'Hagan Olivia V. Swann Chengetai D. Mpamhanga Damian Roland Thomas Waterfield Robin Marlow |
| author_facet | Mark D. Lyttle Helen Groves Thomas C. Williams Simon B. Drysdale Ian Sinha Xinxue Liu Steve Cunningham Dalia Iskander Abigail Maxwell-Hodkinson Shaun O'Hagan Olivia V. Swann Chengetai D. Mpamhanga Damian Roland Thomas Waterfield Robin Marlow |
| author_sort | Mark D. Lyttle |
| collection | DOAJ |
| description | Background In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation’s decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024. Study question We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV. Methods and likely impact We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake. |
| format | Article |
| id | doaj-art-90cef1f8bbcc4de7804c48e38eef2e45 |
| institution | OA Journals |
| issn | 2398-502X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj-art-90cef1f8bbcc4de7804c48e38eef2e452025-08-20T01:58:05ZengWellcomeWellcome Open Research2398-502X2024-12-01610.12688/wellcomeopenres.16778.425971Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations]Mark D. Lyttle0https://orcid.org/0000-0002-8634-7210Helen Groves1Thomas C. Williams2https://orcid.org/0000-0002-3866-1344Simon B. Drysdale3Ian Sinha4Xinxue Liu5Steve Cunningham6https://orcid.org/0000-0001-7342-251XDalia Iskander7Abigail Maxwell-Hodkinson8Shaun O'Hagan9Olivia V. Swann10https://orcid.org/0000-0001-7386-2849Chengetai D. Mpamhanga11Damian Roland12https://orcid.org/0000-0001-9334-5144Thomas Waterfield13Robin Marlow14Faculty of Health and Applied Sciences, University of the West of England, Bristol, UKWellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast, Belfast, UKInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UKOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UKUniversity of Liverpool, Liverpool, UKOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UKCentre for Inflammation Research, University of Edinburgh, Edinburgh, UKDepartment of Anthropology, University College London, London, UKUniversity of Liverpool Medical School, Liverpool, UKWellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast, Belfast, UKDepartment of Child Life and Health, University of Edinburgh, Edinburgh, UKDepartment of Child Life and Health, University of Edinburgh, Edinburgh, UKPaediatric Emergency Medicine Leicester Academic (PEMLA) Group, Leicester Royal Infirmary, Leicester, UKWellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast, Belfast, UKEmergency Department, Bristol Royal Hospital for Children, Bristol, UKBackground In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation’s decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024. Study question We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV. Methods and likely impact We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.https://wellcomeopenresearch.org/articles/6-120/v4COVID-19 Respiratory Syncytial Virus Bronchiolitis Infants Children Palivizumabeng |
| spellingShingle | Mark D. Lyttle Helen Groves Thomas C. Williams Simon B. Drysdale Ian Sinha Xinxue Liu Steve Cunningham Dalia Iskander Abigail Maxwell-Hodkinson Shaun O'Hagan Olivia V. Swann Chengetai D. Mpamhanga Damian Roland Thomas Waterfield Robin Marlow Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations] Wellcome Open Research COVID-19 Respiratory Syncytial Virus Bronchiolitis Infants Children Palivizumab eng |
| title | Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations] |
| title_full | Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations] |
| title_fullStr | Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations] |
| title_full_unstemmed | Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations] |
| title_short | Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” [version 4; peer review: 3 approved, 1 approved with reservations] |
| title_sort | update to study pre protocol for bronchstart the impact of the covid 19 pandemic on the timing age and severity of respiratory syncytial virus rsv emergency presentations a multi centre prospective observational cohort study version 4 peer review 3 approved 1 approved with reservations |
| topic | COVID-19 Respiratory Syncytial Virus Bronchiolitis Infants Children Palivizumab eng |
| url | https://wellcomeopenresearch.org/articles/6-120/v4 |
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