Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study
Objective. Owing to a shortage of kidney donors in Israel, children with end-stage renal disease (ESRD) may stay on maintenance dialysis for a considerable time, placing them at a significant risk. The aim of this study was to understand the causes of mortality. Study Design. Clinical data were coll...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2016/2132387 |
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| author | Daniella Levy Erez Irit Krause Amit Dagan Roxana Cleper Yafa Falush Miriam Davidovits |
| author_facet | Daniella Levy Erez Irit Krause Amit Dagan Roxana Cleper Yafa Falush Miriam Davidovits |
| author_sort | Daniella Levy Erez |
| collection | DOAJ |
| description | Objective. Owing to a shortage of kidney donors in Israel, children with end-stage renal disease (ESRD) may stay on maintenance dialysis for a considerable time, placing them at a significant risk. The aim of this study was to understand the causes of mortality. Study Design. Clinical data were collected retrospectively from the files of children on chronic dialysis (>3 months) during the years 1995–2013 at a single pediatric medical center. Results. 110 patients were enrolled in the study. Mean age was 10.7±5.27 yrs. (range: 1 month–24 yrs). Forty-five children (42%) had dysplastic kidneys and 19 (17.5%) had focal segmental glomerulosclerosis. Twenty-five (22.7%) received peritoneal dialysis, 59 (53.6%) hemodialysis, and 6 (23.6%) both modalities sequentially. Median dialysis duration was 1.46 years (range: 0.25–17.54 years). Mean follow-up was 13.5±5.84 yrs. Seventy-nine patients (71.8%) underwent successful transplantation, 10 (11.2%) had graft failure, and 8 (7.3%) continued dialysis without transplantation. Twelve patients (10.9%) died: 8 of dialysis-associated complications and 4 of their primary illness. The 5-year survival rate was 84%: 90% for patients older than 5 years and 61% for younger patients. Conclusions. Chronic dialysis is a suitable temporary option for children awaiting renal transplantation. Although overall long-term survival rate is high, very young children are at high risk for life-threatening dialysis-associated complications. |
| format | Article |
| id | doaj-art-90cca9941c0a4f56a6aeefafeae0cc04 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-90cca9941c0a4f56a6aeefafeae0cc042025-02-03T01:27:30ZengWileyInternational Journal of Nephrology2090-214X2090-21582016-01-01201610.1155/2016/21323872132387Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center StudyDaniella Levy Erez0Irit Krause1Amit Dagan2Roxana Cleper3Yafa Falush4Miriam Davidovits5Institute of Nephrology, Schneider Children’s Medical Center of Israel, 49202 Petah Tikva, IsraelInstitute of Nephrology, Schneider Children’s Medical Center of Israel, 49202 Petah Tikva, IsraelInstitute of Nephrology, Schneider Children’s Medical Center of Israel, 49202 Petah Tikva, IsraelInstitute of Nephrology, Schneider Children’s Medical Center of Israel, 49202 Petah Tikva, IsraelInstitute of Nephrology, Schneider Children’s Medical Center of Israel, 49202 Petah Tikva, IsraelInstitute of Nephrology, Schneider Children’s Medical Center of Israel, 49202 Petah Tikva, IsraelObjective. Owing to a shortage of kidney donors in Israel, children with end-stage renal disease (ESRD) may stay on maintenance dialysis for a considerable time, placing them at a significant risk. The aim of this study was to understand the causes of mortality. Study Design. Clinical data were collected retrospectively from the files of children on chronic dialysis (>3 months) during the years 1995–2013 at a single pediatric medical center. Results. 110 patients were enrolled in the study. Mean age was 10.7±5.27 yrs. (range: 1 month–24 yrs). Forty-five children (42%) had dysplastic kidneys and 19 (17.5%) had focal segmental glomerulosclerosis. Twenty-five (22.7%) received peritoneal dialysis, 59 (53.6%) hemodialysis, and 6 (23.6%) both modalities sequentially. Median dialysis duration was 1.46 years (range: 0.25–17.54 years). Mean follow-up was 13.5±5.84 yrs. Seventy-nine patients (71.8%) underwent successful transplantation, 10 (11.2%) had graft failure, and 8 (7.3%) continued dialysis without transplantation. Twelve patients (10.9%) died: 8 of dialysis-associated complications and 4 of their primary illness. The 5-year survival rate was 84%: 90% for patients older than 5 years and 61% for younger patients. Conclusions. Chronic dialysis is a suitable temporary option for children awaiting renal transplantation. Although overall long-term survival rate is high, very young children are at high risk for life-threatening dialysis-associated complications.http://dx.doi.org/10.1155/2016/2132387 |
| spellingShingle | Daniella Levy Erez Irit Krause Amit Dagan Roxana Cleper Yafa Falush Miriam Davidovits Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study International Journal of Nephrology |
| title | Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study |
| title_full | Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study |
| title_fullStr | Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study |
| title_full_unstemmed | Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study |
| title_short | Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study |
| title_sort | impact of pediatric chronic dialysis on long term patient outcome single center study |
| url | http://dx.doi.org/10.1155/2016/2132387 |
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