Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study)
The best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of а-interferon...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/333 |
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| author | T. V. Sologub A. A. Shuldyakov L. G. Goryacheva I. P. Baranova YU. N. Linkova A. L. Kovalenko M. G. Romantsov |
| author_facet | T. V. Sologub A. A. Shuldyakov L. G. Goryacheva I. P. Baranova YU. N. Linkova A. L. Kovalenko M. G. Romantsov |
| author_sort | T. V. Sologub |
| collection | DOAJ |
| description | The best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of а-interferon in combination with cycloferon provided remission in 44.1% of the lamivudine-resistant patients. The use of cycloferon in the therapy of chronic hepatitis B made it possible to lower the frequency and manifestation level of the side effects and prevented the lamivudine resistance development and generation of the virus mutants. |
| format | Article |
| id | doaj-art-90c1df6ab07f4d819df9e5881b40f999 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-90c1df6ab07f4d819df9e5881b40f9992025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01559-103741332Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study)T. V. Sologub0A. A. Shuldyakov1L. G. Goryacheva2I. P. Baranova3YU. N. Linkova4A. L. Kovalenko5M. G. Romantsov6I. I. Mechnikov St.Petersburg State Medical AcademySaratov State Medical UniversityResearch Institute of Children Infections, St.PetersburgPenza State Institute of Postgraduate Medical TrainingResearch and Technological Pharmaceutical Co. POLYSAN, St.PetersburgResearch and Technological Pharmaceutical Co. POLYSAN, St.PetersburgI. I. Mechnikov St.Petersburg State Medical AcademyThe best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of а-interferon in combination with cycloferon provided remission in 44.1% of the lamivudine-resistant patients. The use of cycloferon in the therapy of chronic hepatitis B made it possible to lower the frequency and manifestation level of the side effects and prevented the lamivudine resistance development and generation of the virus mutants.https://www.antibiotics-chemotherapy.ru/jour/article/view/333chronic hepatitis bcycloferon |
| spellingShingle | T. V. Sologub A. A. Shuldyakov L. G. Goryacheva I. P. Baranova YU. N. Linkova A. L. Kovalenko M. G. Romantsov Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study) Антибиотики и Химиотерапия chronic hepatitis b cycloferon |
| title | Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study) |
| title_full | Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study) |
| title_fullStr | Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study) |
| title_full_unstemmed | Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study) |
| title_short | Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study) |
| title_sort | cycloferon efficacy of therapy of chronic hepatitis b results of randomized multicentre study |
| topic | chronic hepatitis b cycloferon |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/333 |
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