Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis
Asthma is a chronic inflammatory disease with the main anti-inflammatory drugs for better disease control being steroids or corticosteroids. The use of steroids in asthma patients, in particular in uncontrolled asthma patients, is associated with an increased risk of osteoporosis and fragility fract...
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| author | Fabiana Furci Marco Umberto Scaramozzino Giuseppe Rocco Talesa Corrado Pelaia |
| author_facet | Fabiana Furci Marco Umberto Scaramozzino Giuseppe Rocco Talesa Corrado Pelaia |
| author_sort | Fabiana Furci |
| collection | DOAJ |
| description | Asthma is a chronic inflammatory disease with the main anti-inflammatory drugs for better disease control being steroids or corticosteroids. The use of steroids in asthma patients, in particular in uncontrolled asthma patients, is associated with an increased risk of osteoporosis and fragility fractures. A single oral corticosteroid course increases the risk of osteoporosis and the continual use of inhaled corticosteroids is correlated over time to an increased risk for both bone conditions. With the use of new, available biologic therapies for asthma, perhaps even anticipating the times of their use in therapeutic management, in the current guidelines and with targeted strategies of prevention it may be possible to improve asthma management, preventing some comorbidities, such as osteoporosis. |
| format | Article |
| id | doaj-art-90c0a1c5b4a5412381598637166c11fc |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-90c0a1c5b4a5412381598637166c11fc2025-01-24T13:24:21ZengMDPI AGBiomedicines2227-90592025-01-0113119710.3390/biomedicines13010197Connections and Unmet Needs: Severe Asthma Biologics and OsteoporosisFabiana Furci0Marco Umberto Scaramozzino1Giuseppe Rocco Talesa2Corrado Pelaia3Provincial Healthcare Unit, Section of Allergology, 89900 Vibo Valentia, Italy“La Madonnina” Outpatient Clinic, 89100 Reggio Calabria, ItalyDepartment of Orthopaedics and Traumatology, San Matteo Degli Infermi Hospital, 06049 Spoleto, ItalyDepartment of Medical and Surgical Sciences, University of Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyAsthma is a chronic inflammatory disease with the main anti-inflammatory drugs for better disease control being steroids or corticosteroids. The use of steroids in asthma patients, in particular in uncontrolled asthma patients, is associated with an increased risk of osteoporosis and fragility fractures. A single oral corticosteroid course increases the risk of osteoporosis and the continual use of inhaled corticosteroids is correlated over time to an increased risk for both bone conditions. With the use of new, available biologic therapies for asthma, perhaps even anticipating the times of their use in therapeutic management, in the current guidelines and with targeted strategies of prevention it may be possible to improve asthma management, preventing some comorbidities, such as osteoporosis.https://www.mdpi.com/2227-9059/13/1/197severe asthmabiologicscorticosteroidsinflammationinterleukinsosteoporosis |
| spellingShingle | Fabiana Furci Marco Umberto Scaramozzino Giuseppe Rocco Talesa Corrado Pelaia Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis Biomedicines severe asthma biologics corticosteroids inflammation interleukins osteoporosis |
| title | Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis |
| title_full | Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis |
| title_fullStr | Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis |
| title_full_unstemmed | Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis |
| title_short | Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis |
| title_sort | connections and unmet needs severe asthma biologics and osteoporosis |
| topic | severe asthma biologics corticosteroids inflammation interleukins osteoporosis |
| url | https://www.mdpi.com/2227-9059/13/1/197 |
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