Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1

Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1

Summary: The protein α-synuclein, encoded by SNCA, accumulates in Parkinson’s disease (PD) and other synucleinopathies for reasons that remain unclear. Here, we investigated whether SNCA is regulated in vivo by the RNA-binding protein PUM1. We establish that PUM1 binds to SNCA’s 3′ UTR in mouse and...

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Main Authors: Maximilian Cabaj, Pietro G. Mazzara, Zachary A. Gaertner, Ruizhi Wang, Michaela M. Pauers, Lisa K. Randolph, Cláudio Gouveia Roque, Sean Feeney, Serena Raimo, Nicola de Prisco, Alexei Chemiakine, Xinyuan Wang, Ravi K. Singh, Swetha Rajasekaran, Hari K. Yalamanchili, Wayne Miles, Kristin Baldwin, Chaolin Zhang, Matthew B. Harms, Vikram Khurana, Vicky Brandt, Ulrich Hengst, Rajeshwar Awatramani, Vincenzo A. Gennarino
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009167
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