Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review

This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for its antimicrobial, anti-inflammatory, and antioxidant properties. Recent research emphasizes its positive role in osteogenesis,...

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Main Authors: Vanessa Bertolucci, André Felipe Ninomiya, Giovanna Barbarini Longato, Luisa Oliveira Kaneko, Nilson Nonose, Pedro Paulo Menezes Scariot, Leonardo Henrique Dalcheco Messias
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antioxidants
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Online Access:https://www.mdpi.com/2076-3921/14/1/81
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author Vanessa Bertolucci
André Felipe Ninomiya
Giovanna Barbarini Longato
Luisa Oliveira Kaneko
Nilson Nonose
Pedro Paulo Menezes Scariot
Leonardo Henrique Dalcheco Messias
author_facet Vanessa Bertolucci
André Felipe Ninomiya
Giovanna Barbarini Longato
Luisa Oliveira Kaneko
Nilson Nonose
Pedro Paulo Menezes Scariot
Leonardo Henrique Dalcheco Messias
author_sort Vanessa Bertolucci
collection DOAJ
description This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for its antimicrobial, anti-inflammatory, and antioxidant properties. Recent research emphasizes its positive role in osteogenesis, primarily through the modulation of osteoclast and osteoblast activity via molecular pathways. Key mechanisms include reducing inflammatory cytokines, protecting against oxidative stress, and upregulating growth factor essential for bone formation. While compounds such as Caffeic Acid Phenethyl Ester, Apigenin, Quercetin, and Ferulic Acid have been well-documented, emerging evidence points to the significant roles of less-studied compounds like Pinocembrin, Kaempferol, p-Coumaric acid, and Galangin. This review synthesizes the current literature, focusing on the mechanisms by which these bioactive compounds influence osteogenesis. Firstly, it explores the techniques for characterizing bioactive compounds presented in propolis, the chemogeographic variations in its composition, and the effects of both crude extracts and isolated compounds on bone tissue, offering a comprehensive analysis of recent findings across different experimental models. Further, it discusses the effects of Propolis compounds on bone health. In summary, these compounds modulate signaling pathways, including nuclear factor kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial growth factor, and reactive oxygen species. These pathways influence the receptor activator of nuclear factor kappa-β/receptor activator of nuclear factor kappa-β ligand/osteoprotegerin system, fostering bone cell differentiation. This regulation mitigates excessive osteoclast formation, stimulates osteoblast activity, and ultimately contributes to the restoration of bone homeostasis by maintaining a balanced bone remodeling process.
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spelling doaj-art-90b6a401223d491cbe78256e931202d32025-01-24T13:19:25ZengMDPI AGAntioxidants2076-39212025-01-011418110.3390/antiox14010081Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative ReviewVanessa Bertolucci0André Felipe Ninomiya1Giovanna Barbarini Longato2Luisa Oliveira Kaneko3Nilson Nonose4Pedro Paulo Menezes Scariot5Leonardo Henrique Dalcheco Messias6Research Group on Technology Applied to Exercise Physiology—GTAFE, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista 12916-900, SP, BrazilResearch Group on Technology Applied to Exercise Physiology—GTAFE, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista 12916-900, SP, BrazilResearch Laboratory in Molecular Pharmacology of Bioactive Compounds, São Francisco University, Bragança Paulista 12916-900, SP, BrazilResearch Group on Technology Applied to Exercise Physiology—GTAFE, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista 12916-900, SP, BrazilResearch Group on Technology Applied to Exercise Physiology—GTAFE, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista 12916-900, SP, BrazilResearch Group on Technology Applied to Exercise Physiology—GTAFE, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista 12916-900, SP, BrazilResearch Group on Technology Applied to Exercise Physiology—GTAFE, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista 12916-900, SP, BrazilThis narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for its antimicrobial, anti-inflammatory, and antioxidant properties. Recent research emphasizes its positive role in osteogenesis, primarily through the modulation of osteoclast and osteoblast activity via molecular pathways. Key mechanisms include reducing inflammatory cytokines, protecting against oxidative stress, and upregulating growth factor essential for bone formation. While compounds such as Caffeic Acid Phenethyl Ester, Apigenin, Quercetin, and Ferulic Acid have been well-documented, emerging evidence points to the significant roles of less-studied compounds like Pinocembrin, Kaempferol, p-Coumaric acid, and Galangin. This review synthesizes the current literature, focusing on the mechanisms by which these bioactive compounds influence osteogenesis. Firstly, it explores the techniques for characterizing bioactive compounds presented in propolis, the chemogeographic variations in its composition, and the effects of both crude extracts and isolated compounds on bone tissue, offering a comprehensive analysis of recent findings across different experimental models. Further, it discusses the effects of Propolis compounds on bone health. In summary, these compounds modulate signaling pathways, including nuclear factor kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial growth factor, and reactive oxygen species. These pathways influence the receptor activator of nuclear factor kappa-β/receptor activator of nuclear factor kappa-β ligand/osteoprotegerin system, fostering bone cell differentiation. This regulation mitigates excessive osteoclast formation, stimulates osteoblast activity, and ultimately contributes to the restoration of bone homeostasis by maintaining a balanced bone remodeling process.https://www.mdpi.com/2076-3921/14/1/81oxidative stressosteoclastsosteoblastsinflammationpropolis
spellingShingle Vanessa Bertolucci
André Felipe Ninomiya
Giovanna Barbarini Longato
Luisa Oliveira Kaneko
Nilson Nonose
Pedro Paulo Menezes Scariot
Leonardo Henrique Dalcheco Messias
Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review
Antioxidants
oxidative stress
osteoclasts
osteoblasts
inflammation
propolis
title Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review
title_full Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review
title_fullStr Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review
title_full_unstemmed Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review
title_short Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review
title_sort bioactive compounds from propolis on bone homeostasis a narrative review
topic oxidative stress
osteoclasts
osteoblasts
inflammation
propolis
url https://www.mdpi.com/2076-3921/14/1/81
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AT luisaoliveirakaneko bioactivecompoundsfrompropolisonbonehomeostasisanarrativereview
AT nilsonnonose bioactivecompoundsfrompropolisonbonehomeostasisanarrativereview
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