Longitudinal association of shorter leukocyte telomere length with CSF biomarker dynamics across early Alzheimer's disease stages in at-risk individualsResearch in context

Longitudinal association of shorter leukocyte telomere length with CSF biomarker dynamics across early Alzheimer's disease stages in at-risk individualsResearch in context

Summary: Background: Short telomere length (TL), a hallmark of biological ageing, has been associated with an increased risk of Alzheimer's disease (AD), but its pathophysiological role remains unclear. This study explored the relationship between blood leukocyte TL (LTL), cerebrospinal fluid...

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Main Authors: Blanca Rodríguez-Fernández, Armand González-Escalante, Patricia Genius, Tavia E. Evans, Paula Ortiz-Romero, Carolina Minguillón, Gwendlyn Kollmorgen, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, Arcadi Navarro, Marc Suárez-Calvet, Aleix Sala-Vila, Marta Crous-Bou, Natàlia Vilor-Tejedor, Müge Akinci, Federica Anastasi, Annabella Beteta, Raffaele Cacciaglia, Lidia Canals-Gispert, Alba Cañas-Martínez, Carme Deulofeu, Maria Emilio, Irene Cumplido-Mayoral, Marta del Campo, Sherezade Fuentes, Laura Hernández, Gema Huesa, Jordi Huguet, Esther Jiménez, David López-Martos, Paula Marne, Eleni Palpatzis, Wiesje Pelkmans, Albina Polo, Sandra Pradas, Mahnaz Shekari, Lluís Solsona, Anna Soteras, Núria Tort-Colet, Marc Vilanova, Anna Brugulat-Serrat, Gonzalo Sánchez Benavides, Marta Milà Alomà, David Vállez-García, Gemma Salvadò, Eider Arenaza Urquijo, Oriol Grau Rivera, Karine Fauria, Ana Fernández-Arcos, Laura Stankeviciute, Michalis Kassinopoulos, Anna Coward, Clàudia Porta, Clara Gallay, Aldana Lizarraga, Felipe Hernández Villamizar, Isabel Pérez-Gutiérrez, Noelia Giselle Rugna, Ricardo Aquite Aguilar
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:EBioMedicine
Subjects:
Alzheimer's disease
Preclinical
Glial biomarkers
Cortical thickness
Leukocyte telomere length
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425003305
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