T-bet+CD8+ T cells govern anti-PD-1 responses in microsatellite-stable gastric cancers

T-bet+CD8+ T cells govern anti-PD-1 responses in microsatellite-stable gastric cancers

Abstract More than 90% of advanced gastric cancers (GC) are microsatellite-stable (MSS). Compared to the high response rate of immune checkpoint inhibitors (ICI) in microsatellite-instability-high (MSI-H) GCs, only 10% of unstratified MSS GCs respond to ICIs. In this study, we apply semi-supervised...

Full description

Saved in:
Bibliographic Details
Main Authors: Shiying Tang, Xiaofang Che, Jinyan Wang, Ce Li, Xin He, Kezuo Hou, Xiaojie Zhang, Jia Guo, Bowen Yang, Danni Li, Lili Cao, Xiujuan Qu, Zhenning Wang, Yunpeng Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58958-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items