FTO-mediated MMP1 m6A modification promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the ERK pathway in congenital scoliosis

FTO-mediated MMP1 m6A modification promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the ERK pathway in congenital scoliosis

Abstract Bone formation, metabolism, and the stability of the bone marrow microenvironment are all impacted by the imbalance in the differentiation potential of bone marrow mesenchymal stem cells (BMSCs). Despite this, it is unknown how BMSCs affect congenital scoliosis (CS). As a result, our resear...

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Bibliographic Details
Main Authors: Jie Dai, Gang Xiang, Jiong Li, Gengming Zhang, Guanteng Yang, Lige Xiao, Yunjia Wang, Hongqi Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Congenital scoliosis
Bone marrow mesenchymal stem cells
m6A methylation
Osteogenic differentiation
Signal transduction pathway
Online Access:https://doi.org/10.1038/s41598-025-13044-w
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