Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up)
Aim. To analyze the lipid profile changes during the acute phase of coronavirus disease 2019 (COVID-19) and within 12 months after discharge from the hospital (post-Covid period) in comparison with the lipid profile of patients before COVID-19.Material and methods. The subanalysis of the registry wa...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2024-04-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5716 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849341320037924864 |
|---|---|
| author | G. P. Arutyunov E. I. Tarlovskaya A. G. Arutyunov D. S. Polyakov N. Yu. Grigorieva I. V. Gubareva U. K. Kamilova Z. F. Kim A. S. Kuznetsova T. Yu. Kuznetsova D. Yu. Ruzanov A. V. Svarovskaya E. А. Smirnova A. B. Sugraliev I. A. Frolova G. T. Aimakhanova T. I. Batluk R. A. Bashkinov I. V. Bikushova E. D. Gordeychuk E. Yu. Gubareva D. S. Evdokimov G. A. Zakirova A. O. Loginova E. S. Melnikov N. B. Moiseenko M. A. Trubnikova S. Yu. Shcherbakov |
| author_facet | G. P. Arutyunov E. I. Tarlovskaya A. G. Arutyunov D. S. Polyakov N. Yu. Grigorieva I. V. Gubareva U. K. Kamilova Z. F. Kim A. S. Kuznetsova T. Yu. Kuznetsova D. Yu. Ruzanov A. V. Svarovskaya E. А. Smirnova A. B. Sugraliev I. A. Frolova G. T. Aimakhanova T. I. Batluk R. A. Bashkinov I. V. Bikushova E. D. Gordeychuk E. Yu. Gubareva D. S. Evdokimov G. A. Zakirova A. O. Loginova E. S. Melnikov N. B. Moiseenko M. A. Trubnikova S. Yu. Shcherbakov |
| author_sort | G. P. Arutyunov |
| collection | DOAJ |
| description | Aim. To analyze the lipid profile changes during the acute phase of coronavirus disease 2019 (COVID-19) and within 12 months after discharge from the hospital (post-Covid period) in comparison with the lipid profile of patients before COVID-19.Material and methods. The subanalysis of the registry was carried out as follows: clinical investigators in each of the centers included patients in the AKTIV registry selected from the database patients who met three following criteria: (1) availability of lipid profile test no more than 60 days before COVID-19; (2) availability of lipid profile test during the acute period; (3) availability of lipid profile test within 6-12 months after discharge from the hospital.Results. In patients after COVID-19, a decrease in the levels of all lipid profile parameters in the acute COVID-19 phase and their subsequent increase were found.In the post-COVID-19 period, 25,7% of patients experienced an increase in lipid profile parameters (increased levels of total cholesterol (TC) and/or cholesterol, low-density lipoproteins and/or triglycerides and/or cholesterol excluding high-density lipoproteins by ≥0,5 mmol/l) despite the fact that lipid-lowering therapy in these patients was at least no worse than in patients without lipid profile changes.Multivariate analysis found that such variables as age (direct relationship), body mass index (direct relationship), estimated glomerular filtration rate in the acute phase (inverse relationship) and cholesterol level excluding high-density lipoproteins in the acute period (inverse relationship), as well as heart failure, obesity and cytokine storm in the acute COVID-19 phase are independent predictors of an increase in one or more lipid parameters by ≥0,5 mmol/l over 6-12 months of post-COVID-19 period.Conclusion. COVID-19 likely contributes to the onset and/or progression of lipid metabolism disorders in COVID-19 survivors (Eurasian population). |
| format | Article |
| id | doaj-art-90ac8f2fff1947e2a4f881f447dfd356 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2024-04-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-90ac8f2fff1947e2a4f881f447dfd3562025-08-20T03:43:40Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202024-04-0129310.15829/1560-4071-2024-57163989Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up)G. P. Arutyunov0E. I. Tarlovskaya1A. G. Arutyunov2D. S. Polyakov3N. Yu. Grigorieva4I. V. Gubareva5U. K. Kamilova6Z. F. Kim7A. S. Kuznetsova8T. Yu. Kuznetsova9D. Yu. Ruzanov10A. V. Svarovskaya11E. А. Smirnova12A. B. Sugraliev13I. A. Frolova14G. T. Aimakhanova15T. I. Batluk16R. A. Bashkinov17I. V. Bikushova18E. D. Gordeychuk19E. Yu. Gubareva20D. S. Evdokimov21G. A. Zakirova22A. O. Loginova23E. S. Melnikov24N. B. Moiseenko25M. A. Trubnikova26S. Yu. Shcherbakov27Eurasian Association of Therapists; Pirogov Russian National Research Medical UniversityEurasian Association of Therapists; Privolzhsky Research Medical UniversityEurasian Association of Therapists; S. Avdalbekyan National Institute of HealthPrivolzhsky Research Medical University; Lobachevsky National Research State UniversityLobachevsky National Research State UniversitySamara State Medical UniversityRepublican Specialized Scientific and Practical Medical Center for Therapy and Medical RehabilitationCity Clinical Hospital № 7 of KazanSouth Ural State Medical UniversityPetrozavodsk State UniversityGomel State Medical UniversityCardiology Research Institute, Tomsk National Medical Research CenterRyazan State Medical UniversityAsfendiyarov Kazakh National Medical UniversityPrivolzhsky District Medical Center of the Federal Medical and Biological AgencyAsfendiyarov Kazakh National Medical UniversityEurasian Association of TherapistsEurasian Association of Therapists; I.I. Mechnikov North-Western State Medical UniversityRyazan State Medical UniversityEurasian Association of Therapists; Pirogov Russian National Research Medical UniversitySamara State Medical UniversityI.I. Mechnikov North-Western State Medical UniversityRepublican Specialized Scientific and Practical Medical Center for Therapy and Medical RehabilitationResearch Institute — Korolev Specialized Cardiac Surgery Clinical HospitalEurasian Association of Therapists; I.I. Mechnikov North-Western State Medical UniversityLobachevsky National Research State UniversityEurasian Association of Therapists; LLC "Fomin Clinic"Kazan State Medical Academy — branch of the Russian Medical Academy of Continuous Professional EducationAim. To analyze the lipid profile changes during the acute phase of coronavirus disease 2019 (COVID-19) and within 12 months after discharge from the hospital (post-Covid period) in comparison with the lipid profile of patients before COVID-19.Material and methods. The subanalysis of the registry was carried out as follows: clinical investigators in each of the centers included patients in the AKTIV registry selected from the database patients who met three following criteria: (1) availability of lipid profile test no more than 60 days before COVID-19; (2) availability of lipid profile test during the acute period; (3) availability of lipid profile test within 6-12 months after discharge from the hospital.Results. In patients after COVID-19, a decrease in the levels of all lipid profile parameters in the acute COVID-19 phase and their subsequent increase were found.In the post-COVID-19 period, 25,7% of patients experienced an increase in lipid profile parameters (increased levels of total cholesterol (TC) and/or cholesterol, low-density lipoproteins and/or triglycerides and/or cholesterol excluding high-density lipoproteins by ≥0,5 mmol/l) despite the fact that lipid-lowering therapy in these patients was at least no worse than in patients without lipid profile changes.Multivariate analysis found that such variables as age (direct relationship), body mass index (direct relationship), estimated glomerular filtration rate in the acute phase (inverse relationship) and cholesterol level excluding high-density lipoproteins in the acute period (inverse relationship), as well as heart failure, obesity and cytokine storm in the acute COVID-19 phase are independent predictors of an increase in one or more lipid parameters by ≥0,5 mmol/l over 6-12 months of post-COVID-19 period.Conclusion. COVID-19 likely contributes to the onset and/or progression of lipid metabolism disorders in COVID-19 survivors (Eurasian population).https://russjcardiol.elpub.ru/jour/article/view/5716covid-19dyslipidemialipid profile |
| spellingShingle | G. P. Arutyunov E. I. Tarlovskaya A. G. Arutyunov D. S. Polyakov N. Yu. Grigorieva I. V. Gubareva U. K. Kamilova Z. F. Kim A. S. Kuznetsova T. Yu. Kuznetsova D. Yu. Ruzanov A. V. Svarovskaya E. А. Smirnova A. B. Sugraliev I. A. Frolova G. T. Aimakhanova T. I. Batluk R. A. Bashkinov I. V. Bikushova E. D. Gordeychuk E. Yu. Gubareva D. S. Evdokimov G. A. Zakirova A. O. Loginova E. S. Melnikov N. B. Moiseenko M. A. Trubnikova S. Yu. Shcherbakov Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up) Российский кардиологический журнал covid-19 dyslipidemia lipid profile |
| title | Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up) |
| title_full | Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up) |
| title_fullStr | Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up) |
| title_full_unstemmed | Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up) |
| title_short | Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up) |
| title_sort | lipid profile changes after the acute covid 19 period sub analysis of the international registry dynamics analysis of comorbidities in sars cov 2 survivors aktiv sars cov 2 12 month follow up |
| topic | covid-19 dyslipidemia lipid profile |
| url | https://russjcardiol.elpub.ru/jour/article/view/5716 |
| work_keys_str_mv | AT gparutyunov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT eitarlovskaya lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT agarutyunov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT dspolyakov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT nyugrigorieva lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT ivgubareva lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT ukkamilova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT zfkim lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT askuznetsova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT tyukuznetsova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT dyuruzanov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT avsvarovskaya lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT easmirnova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT absugraliev lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT iafrolova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT gtaimakhanova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT tibatluk lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT rabashkinov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT ivbikushova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT edgordeychuk lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT eyugubareva lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT dsevdokimov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT gazakirova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT aologinova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT esmelnikov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT nbmoiseenko lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT matrubnikova lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup AT syushcherbakov lipidprofilechangesaftertheacutecovid19periodsubanalysisoftheinternationalregistrydynamicsanalysisofcomorbiditiesinsarscov2survivorsaktivsarscov212monthfollowup |