Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls
Background. Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls. Aim. Using a novel magnetic resonanc...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/498296 |
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| author | Niraj S. Patel Michael R. Peterson Grace Y. Lin Ariel Feldstein Bernd Schnabl Ricki Bettencourt Ekihiro Seki Claude B. Sirlin Rohit Loomba |
| author_facet | Niraj S. Patel Michael R. Peterson Grace Y. Lin Ariel Feldstein Bernd Schnabl Ricki Bettencourt Ekihiro Seki Claude B. Sirlin Rohit Loomba |
| author_sort | Niraj S. Patel |
| collection | DOAJ |
| description | Background. Ectopic fat deposition in the pancreas and its relationship
with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls.
Aim. Using a novel magnetic resonance imaging (MRI) based biomarker, the proton-density-fat-fraction (MRI-PDFF),
we compared pancreatic fat content in patients with biopsy-proven NAFLD to healthy controls and determined whether it is
associated with insulin resistance and liver fat content. Methods. This nested case-control study was derived from two prospective studies including
43 patients with biopsy-proven NAFLD and 49 healthy controls who underwent biochemical testing and MRI.
Results. Compared to healthy controls, patients with NAFLD had significantly higher pancreatic MRI-PDFF (3.6% versus 8.5%, P value <0.001), and these results remained consistent in multivariable-adjusted models
including age, sex, body mass index, and diabetes (P value =0.03). We found a strong correlation between
hepatic and pancreatic MRI-PDFF (Spearman correlation, P = 0.57, P value <0.001). Participants with increased
insulin resistance determined by homeostatic-model-of-insulin-resistance (HOMA-IR) greater than 2.5 had higher
pancreatic (7.3% versus 4.5%, P value =0.015) and liver (13.5% versus 4.0%, P value <0.001) MRI-PDFF.
Conclusion. Patients with NAFLD have greater pancreatic fat than normal controls. Insulin resistance is associated with liver and pancreatic fat accumulation. |
| format | Article |
| id | doaj-art-90ac09ade9864c4f829998525dc16e2a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-90ac09ade9864c4f829998525dc16e2a2025-02-03T07:24:46ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/498296498296Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal ControlsNiraj S. Patel0Michael R. Peterson1Grace Y. Lin2Ariel Feldstein3Bernd Schnabl4Ricki Bettencourt5Ekihiro Seki6Claude B. Sirlin7Rohit Loomba8Division of Internal Medicine, Department of Medicine, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USADepartment of Pathology, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USADepartment of Pathology, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USADivision of Gastroenterology, Department of Pediatrics, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USADivision of Gastroenterology, Department of Medicine, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USADivision of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USADivision of Gastroenterology, Department of Medicine, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USALiver Imaging Group, Department of Radiology, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USADivision of Gastroenterology, Department of Medicine, University of California at San Diego, UC San Diego Health System, 9500 Gilman Drive, MC 0063, La Jolla, CA 92093, USABackground. Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls. Aim. Using a novel magnetic resonance imaging (MRI) based biomarker, the proton-density-fat-fraction (MRI-PDFF), we compared pancreatic fat content in patients with biopsy-proven NAFLD to healthy controls and determined whether it is associated with insulin resistance and liver fat content. Methods. This nested case-control study was derived from two prospective studies including 43 patients with biopsy-proven NAFLD and 49 healthy controls who underwent biochemical testing and MRI. Results. Compared to healthy controls, patients with NAFLD had significantly higher pancreatic MRI-PDFF (3.6% versus 8.5%, P value <0.001), and these results remained consistent in multivariable-adjusted models including age, sex, body mass index, and diabetes (P value =0.03). We found a strong correlation between hepatic and pancreatic MRI-PDFF (Spearman correlation, P = 0.57, P value <0.001). Participants with increased insulin resistance determined by homeostatic-model-of-insulin-resistance (HOMA-IR) greater than 2.5 had higher pancreatic (7.3% versus 4.5%, P value =0.015) and liver (13.5% versus 4.0%, P value <0.001) MRI-PDFF. Conclusion. Patients with NAFLD have greater pancreatic fat than normal controls. Insulin resistance is associated with liver and pancreatic fat accumulation.http://dx.doi.org/10.1155/2013/498296 |
| spellingShingle | Niraj S. Patel Michael R. Peterson Grace Y. Lin Ariel Feldstein Bernd Schnabl Ricki Bettencourt Ekihiro Seki Claude B. Sirlin Rohit Loomba Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls Gastroenterology Research and Practice |
| title | Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls |
| title_full | Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls |
| title_fullStr | Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls |
| title_full_unstemmed | Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls |
| title_short | Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls |
| title_sort | insulin resistance increases mri estimated pancreatic fat in nonalcoholic fatty liver disease and normal controls |
| url | http://dx.doi.org/10.1155/2013/498296 |
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