Usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adults
Abstract Measuring skeletal muscle mass index using bioelectrical impedance analysis or dual-energy X-ray absorptiometry is challenging for home care patients and those with implanted devices. Contrastingly, ultrasound measurement of skeletal muscle mass is a simple and non-invasive method. We aimed...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-09430-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849333125269684224 |
|---|---|
| author | Masaaki Onishi Tomoya Iseki Shotaro Tsuji Kensaku Shojima Hiromitsu Yamazaki Yasuyuki Nagasawa Kayoko Tamaki Takara Mori Yosuke Wada Hiroshi Kusunoki Masako Shiramizu Ryota Matsuzawa Koutatsu Nagai Toshiya Tachibana Ken Shinmura |
| author_facet | Masaaki Onishi Tomoya Iseki Shotaro Tsuji Kensaku Shojima Hiromitsu Yamazaki Yasuyuki Nagasawa Kayoko Tamaki Takara Mori Yosuke Wada Hiroshi Kusunoki Masako Shiramizu Ryota Matsuzawa Koutatsu Nagai Toshiya Tachibana Ken Shinmura |
| author_sort | Masaaki Onishi |
| collection | DOAJ |
| description | Abstract Measuring skeletal muscle mass index using bioelectrical impedance analysis or dual-energy X-ray absorptiometry is challenging for home care patients and those with implanted devices. Contrastingly, ultrasound measurement of skeletal muscle mass is a simple and non-invasive method. We aimed to investigate quadriceps muscle cross-sectional area measured using a newly developed ultrasonic muscle imaging system to serve as a diagnostic tool for sarcopenia. The cross-sectional study including 510 independent adults aged 65 years and older (180 men; median age, 75 years) was performed between October 2021 and December 2022. Quadriceps muscle cross-sectional area of the dominant leg was measured, and the average value was analyzed for correlation with body composition indices measured using the bioelectrical impedance analysis method, muscle strength and physical performance tests. Quadriceps muscle cross-sectional area showed a good correlation with skeletal muscle mass index (R = 0.78, P < 0.001), handgrip strength (R = 0.70, P < 0.001), and knee extension strength (R = 0.68, P < 0.001). This study demonstrated that quadriceps muscle cross-sectional area using a newly developed ultrasonic system shows a strong correlation with skeletal muscle mass index and muscle strength. These findings suggest that this system could be an alternative to bioelectrical impedance analysis for the diagnosis of sarcopenia. |
| format | Article |
| id | doaj-art-90a967186b804b1ebfc7b6bc772f9182 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-90a967186b804b1ebfc7b6bc772f91822025-08-20T03:45:59ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-09430-zUsefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adultsMasaaki Onishi0Tomoya Iseki1Shotaro Tsuji2Kensaku Shojima3Hiromitsu Yamazaki4Yasuyuki Nagasawa5Kayoko Tamaki6Takara Mori7Yosuke Wada8Hiroshi Kusunoki9Masako Shiramizu10Ryota Matsuzawa11Koutatsu Nagai12Toshiya Tachibana13Ken Shinmura14Department of Orthopaedic Surgery, Hyogo Medical University School of MedicineDepartment of Orthopaedic Surgery, Hyogo Medical University School of MedicineDepartment of Orthopaedic Surgery, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineDepartment of Dental Hygiene, Kyoto Koka Women’s CollegeDepartment of Physical Therapy, School of Rehabilitation, Hyogo Medical UniversityDepartment of Physical Therapy, School of Rehabilitation, Hyogo Medical UniversityDepartment of Orthopaedic Surgery, Hyogo Medical University School of MedicineDepartment of General Internal Medicine, Hyogo Medical University School of MedicineAbstract Measuring skeletal muscle mass index using bioelectrical impedance analysis or dual-energy X-ray absorptiometry is challenging for home care patients and those with implanted devices. Contrastingly, ultrasound measurement of skeletal muscle mass is a simple and non-invasive method. We aimed to investigate quadriceps muscle cross-sectional area measured using a newly developed ultrasonic muscle imaging system to serve as a diagnostic tool for sarcopenia. The cross-sectional study including 510 independent adults aged 65 years and older (180 men; median age, 75 years) was performed between October 2021 and December 2022. Quadriceps muscle cross-sectional area of the dominant leg was measured, and the average value was analyzed for correlation with body composition indices measured using the bioelectrical impedance analysis method, muscle strength and physical performance tests. Quadriceps muscle cross-sectional area showed a good correlation with skeletal muscle mass index (R = 0.78, P < 0.001), handgrip strength (R = 0.70, P < 0.001), and knee extension strength (R = 0.68, P < 0.001). This study demonstrated that quadriceps muscle cross-sectional area using a newly developed ultrasonic system shows a strong correlation with skeletal muscle mass index and muscle strength. These findings suggest that this system could be an alternative to bioelectrical impedance analysis for the diagnosis of sarcopenia.https://doi.org/10.1038/s41598-025-09430-zFrailtyOlder adultsQuadriceps muscleSarcopeniaSkeletal muscle mass indexUltrasound |
| spellingShingle | Masaaki Onishi Tomoya Iseki Shotaro Tsuji Kensaku Shojima Hiromitsu Yamazaki Yasuyuki Nagasawa Kayoko Tamaki Takara Mori Yosuke Wada Hiroshi Kusunoki Masako Shiramizu Ryota Matsuzawa Koutatsu Nagai Toshiya Tachibana Ken Shinmura Usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adults Scientific Reports Frailty Older adults Quadriceps muscle Sarcopenia Skeletal muscle mass index Ultrasound |
| title | Usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adults |
| title_full | Usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adults |
| title_fullStr | Usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adults |
| title_full_unstemmed | Usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adults |
| title_short | Usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community-dwelling older adults |
| title_sort | usefulness of a newly developed ultrasonic system to estimate skeletal muscle mass and muscle strength in community dwelling older adults |
| topic | Frailty Older adults Quadriceps muscle Sarcopenia Skeletal muscle mass index Ultrasound |
| url | https://doi.org/10.1038/s41598-025-09430-z |
| work_keys_str_mv | AT masaakionishi usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT tomoyaiseki usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT shotarotsuji usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT kensakushojima usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT hiromitsuyamazaki usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT yasuyukinagasawa usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT kayokotamaki usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT takaramori usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT yosukewada usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT hiroshikusunoki usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT masakoshiramizu usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT ryotamatsuzawa usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT koutatsunagai usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT toshiyatachibana usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults AT kenshinmura usefulnessofanewlydevelopedultrasonicsystemtoestimateskeletalmusclemassandmusclestrengthincommunitydwellingolderadults |