Not all dimers are equal
Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2025-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/106980 |
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| _version_ | 1850194851239297024 |
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| author | Jeet H Patel Mary C Mullins |
| author_facet | Jeet H Patel Mary C Mullins |
| author_sort | Jeet H Patel |
| collection | DOAJ |
| description | Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer. |
| format | Article |
| id | doaj-art-90a3e4c8c6d24024b0ddd58c3ba4702c |
| institution | OA Journals |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-90a3e4c8c6d24024b0ddd58c3ba4702c2025-08-20T02:13:54ZengeLife Sciences Publications LtdeLife2050-084X2025-05-011410.7554/eLife.106980Not all dimers are equalJeet H Patel0https://orcid.org/0000-0002-0214-4484Mary C Mullins1https://orcid.org/0000-0002-9979-1564Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, United StatesDepartment of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, United StatesDisease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.https://elifesciences.org/articles/106980cell signalingBMP4prodomaindevelopmental biologyhuman mutations |
| spellingShingle | Jeet H Patel Mary C Mullins Not all dimers are equal eLife cell signaling BMP4 prodomain developmental biology human mutations |
| title | Not all dimers are equal |
| title_full | Not all dimers are equal |
| title_fullStr | Not all dimers are equal |
| title_full_unstemmed | Not all dimers are equal |
| title_short | Not all dimers are equal |
| title_sort | not all dimers are equal |
| topic | cell signaling BMP4 prodomain developmental biology human mutations |
| url | https://elifesciences.org/articles/106980 |
| work_keys_str_mv | AT jeethpatel notalldimersareequal AT marycmullins notalldimersareequal |