A case of chorea with cognitive impairment associated with polycythemia vera
Polycythemia vera (PV) is a clonal myeloproliferative disorder that is often associated with neurological symptoms. Rare manifestations of PV may include movement disorders (mainly chorea) and cognitive impairment (CI), which are fully or partially reversible with appropriate treatment. We present a...
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| Language: | Russian |
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IMA-PRESS LLC
2023-12-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/2145 |
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| author | Yu. A. Shpilyukova O. V. Smetanina A. A. Kolpina S. N. Illarioshkin |
| author_facet | Yu. A. Shpilyukova O. V. Smetanina A. A. Kolpina S. N. Illarioshkin |
| author_sort | Yu. A. Shpilyukova |
| collection | DOAJ |
| description | Polycythemia vera (PV) is a clonal myeloproliferative disorder that is often associated with neurological symptoms. Rare manifestations of PV may include movement disorders (mainly chorea) and cognitive impairment (CI), which are fully or partially reversible with appropriate treatment. We present a case of chorea with CI in a 69-year-old man with a confirmed с1849G>T (V617F) mutation in the JAK2 gene with no vascular pathology on neuroimaging. In this patient, there is a clear correlation between the regression of the movement disorders with therapeutic phlebotomy and the start of treatment with hydroxyurea, which allows the conclusion that chorea has the secondary form. The cognitive symptoms remained at the same level after the start of treatment and during the one-year follow-up and did not develop further. In view of the patient's age, a concomitant neurodegenerative disease cannot be ruled out. In elderly patients with new-onset chorea and CI, it is therefore important to consider PV as a possible cause of these disorders, as early diagnosis of this condition allows timely initiation of effective treatment and prevention of the development of complications. |
| format | Article |
| id | doaj-art-90a3310bd711420ea24893e738e6875e |
| institution | OA Journals |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj-art-90a3310bd711420ea24893e738e6875e2025-08-20T02:16:18ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422023-12-0115610110810.14412/20742711-2023-6-101-1081449A case of chorea with cognitive impairment associated with polycythemia veraYu. A. Shpilyukova0O. V. Smetanina1A. A. Kolpina2S. N. Illarioshkin3Research Centre of NeurologyResearch Centre of Neurology“Сhaika Clinics” LLCResearch Centre of NeurologyPolycythemia vera (PV) is a clonal myeloproliferative disorder that is often associated with neurological symptoms. Rare manifestations of PV may include movement disorders (mainly chorea) and cognitive impairment (CI), which are fully or partially reversible with appropriate treatment. We present a case of chorea with CI in a 69-year-old man with a confirmed с1849G>T (V617F) mutation in the JAK2 gene with no vascular pathology on neuroimaging. In this patient, there is a clear correlation between the regression of the movement disorders with therapeutic phlebotomy and the start of treatment with hydroxyurea, which allows the conclusion that chorea has the secondary form. The cognitive symptoms remained at the same level after the start of treatment and during the one-year follow-up and did not develop further. In view of the patient's age, a concomitant neurodegenerative disease cannot be ruled out. In elderly patients with new-onset chorea and CI, it is therefore important to consider PV as a possible cause of these disorders, as early diagnosis of this condition allows timely initiation of effective treatment and prevention of the development of complications.https://nnp.ima-press.net/nnp/article/view/2145polycythemia verachoreacognitive impairmentdiagnosis |
| spellingShingle | Yu. A. Shpilyukova O. V. Smetanina A. A. Kolpina S. N. Illarioshkin A case of chorea with cognitive impairment associated with polycythemia vera Неврология, нейропсихиатрия, психосоматика polycythemia vera chorea cognitive impairment diagnosis |
| title | A case of chorea with cognitive impairment associated with polycythemia vera |
| title_full | A case of chorea with cognitive impairment associated with polycythemia vera |
| title_fullStr | A case of chorea with cognitive impairment associated with polycythemia vera |
| title_full_unstemmed | A case of chorea with cognitive impairment associated with polycythemia vera |
| title_short | A case of chorea with cognitive impairment associated with polycythemia vera |
| title_sort | case of chorea with cognitive impairment associated with polycythemia vera |
| topic | polycythemia vera chorea cognitive impairment diagnosis |
| url | https://nnp.ima-press.net/nnp/article/view/2145 |
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