AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials.
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The applicati...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0159026&type=printable |
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| _version_ | 1850232491663687680 |
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| author | Graham M Wheeler Michael J Sweeting Adrian P Mander |
| author_facet | Graham M Wheeler Michael J Sweeting Adrian P Mander |
| author_sort | Graham M Wheeler |
| collection | DOAJ |
| description | In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities. |
| format | Article |
| id | doaj-art-90a309fbd81e462cbc9faf8912f6a8e2 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-90a309fbd81e462cbc9faf8912f6a8e22025-08-20T02:03:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01117e015902610.1371/journal.pone.0159026AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials.Graham M WheelerMichael J SweetingAdrian P ManderIn phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0159026&type=printable |
| spellingShingle | Graham M Wheeler Michael J Sweeting Adrian P Mander AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. PLoS ONE |
| title | AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. |
| title_full | AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. |
| title_fullStr | AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. |
| title_full_unstemmed | AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. |
| title_short | AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. |
| title_sort | aplusb a web application for investigating a b designs for phase i cancer clinical trials |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0159026&type=printable |
| work_keys_str_mv | AT grahammwheeler aplusbawebapplicationforinvestigatingabdesignsforphaseicancerclinicaltrials AT michaeljsweeting aplusbawebapplicationforinvestigatingabdesignsforphaseicancerclinicaltrials AT adrianpmander aplusbawebapplicationforinvestigatingabdesignsforphaseicancerclinicaltrials |