Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study
Helicobacter pylori (H. pylori) recurrence remains a significant public health concern. The study aimed to assess H. pylori reinfection rate and identify its risk factors in China. This prospective open cohort, observational study was performed at 18 hospitals across 15 provinces in China. Consecuti...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1737579 |
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| author | Yong Xie Conghua Song Hong Cheng Canxia Xu Zhenyu Zhang Jiangbin Wang Lijuan Huo Qin Du Jianming Xu Ye Chen Xiaomei Zhang Guoxin Zhang Guibin Yang Xiuli Zuo Tao Guo Yapi Lu Fen Wang Xuehong Wang Kun Zhuang Shiyao Chen Wenzhong Liu Nonghua Lu |
| author_facet | Yong Xie Conghua Song Hong Cheng Canxia Xu Zhenyu Zhang Jiangbin Wang Lijuan Huo Qin Du Jianming Xu Ye Chen Xiaomei Zhang Guoxin Zhang Guibin Yang Xiuli Zuo Tao Guo Yapi Lu Fen Wang Xuehong Wang Kun Zhuang Shiyao Chen Wenzhong Liu Nonghua Lu |
| author_sort | Yong Xie |
| collection | DOAJ |
| description | Helicobacter pylori (H. pylori) recurrence remains a significant public health concern. The study aimed to assess H. pylori reinfection rate and identify its risk factors in China. This prospective open cohort, observational study was performed at 18 hospitals across 15 provinces in China. Consecutive patients who received the successful initial eradication during 1 January 2012 and 31 December 2018 were eligible for enrolment. H. pylori recurrence was defined as reinfection that occurred at more than the 12-month interval after successful initial eradication. Surveyed risk factors that might be associated with reinfection were preliminarily estimated by log-rank test and further determined by Cox regression model to calculate the hazard ratio (HR) and 95% confidence interval (CI). A total of 5193 subjects enrolled in the study. The follow-up intervals varied from 6 to 84 months with a general follow-up rate of 67.9%. Annual reinfection rate was 1.5% (95% CI: 1.2–1.8) per person-year. H. pylori reinfection was independently associated with the following five risk factors: minority groups (HR = 4.7, 95% CI: 1.6–13.9), the education at lower levels (HR = 1.7, 95% CI: 1.1–2.6), a family history of gastric cancer (HR = 9.9, 95% CI: 6.6–14.7), and the residence located in Western China (HR = 5.5, 95% CI: 2.6–11.5) following by in Central China (HR = 4.9, 95% CI: 3–8.1) (all P < 0.05). Reinfection rate of H. pylori in China is relatively low. Patients with specific properties of ethnic groups, education level, family history, or residence location appear to be at higher risk for reinfection. |
| format | Article |
| id | doaj-art-90a17b6ecce248ec893a8f8a996acbcc |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-90a17b6ecce248ec893a8f8a996acbcc2025-08-20T03:08:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-019154855710.1080/22221751.2020.1737579Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational studyYong Xie0Conghua Song1Hong Cheng2Canxia Xu3Zhenyu Zhang4Jiangbin Wang5Lijuan Huo6Qin Du7Jianming Xu8Ye Chen9Xiaomei Zhang10Guoxin Zhang11Guibin Yang12Xiuli Zuo13Tao Guo14Yapi Lu15Fen Wang16Xuehong Wang17Kun Zhuang18Shiyao Chen19Wenzhong Liu20Nonghua Lu21Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaDepartment of Gastroenterology, Peking University First Hospital, Beijing, People’s Republic of ChinaDepartment of Gastroenterology, 3rd Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaDepartment of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Gastroenterology, Sino-Japanese Friendship Hospital of Jilin University, Changchun, People’s Republic of ChinaDepartment of Gastroenterology, First Affiliated Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, People’s Republic of ChinaDepartment of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of ChinaDepartment of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaDepartment of Gastroenterology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, People’s Republic of ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Gastroenterology, Aerospace Center Hospital, Beijing, People’s Republic of ChinaDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, People’s Republic of ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Beijing, People’s Republic of ChinaDepartment of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, People’s Republic of ChinaDepartment of Gastroenterology, 3rd Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaDepartment of Gastroenterology, Affiliated Hospital of Qinghai University, Xining, People’s Republic of ChinaDepartment of Gastroenterology, Xi’an Central Hospital, Xi’an, People’s Republic of ChinaDepartment of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaHelicobacter pylori (H. pylori) recurrence remains a significant public health concern. The study aimed to assess H. pylori reinfection rate and identify its risk factors in China. This prospective open cohort, observational study was performed at 18 hospitals across 15 provinces in China. Consecutive patients who received the successful initial eradication during 1 January 2012 and 31 December 2018 were eligible for enrolment. H. pylori recurrence was defined as reinfection that occurred at more than the 12-month interval after successful initial eradication. Surveyed risk factors that might be associated with reinfection were preliminarily estimated by log-rank test and further determined by Cox regression model to calculate the hazard ratio (HR) and 95% confidence interval (CI). A total of 5193 subjects enrolled in the study. The follow-up intervals varied from 6 to 84 months with a general follow-up rate of 67.9%. Annual reinfection rate was 1.5% (95% CI: 1.2–1.8) per person-year. H. pylori reinfection was independently associated with the following five risk factors: minority groups (HR = 4.7, 95% CI: 1.6–13.9), the education at lower levels (HR = 1.7, 95% CI: 1.1–2.6), a family history of gastric cancer (HR = 9.9, 95% CI: 6.6–14.7), and the residence located in Western China (HR = 5.5, 95% CI: 2.6–11.5) following by in Central China (HR = 4.9, 95% CI: 3–8.1) (all P < 0.05). Reinfection rate of H. pylori in China is relatively low. Patients with specific properties of ethnic groups, education level, family history, or residence location appear to be at higher risk for reinfection.https://www.tandfonline.com/doi/10.1080/22221751.2020.1737579Helicobacter pylorirecurrencereinfectionrisk factorepidemiology |
| spellingShingle | Yong Xie Conghua Song Hong Cheng Canxia Xu Zhenyu Zhang Jiangbin Wang Lijuan Huo Qin Du Jianming Xu Ye Chen Xiaomei Zhang Guoxin Zhang Guibin Yang Xiuli Zuo Tao Guo Yapi Lu Fen Wang Xuehong Wang Kun Zhuang Shiyao Chen Wenzhong Liu Nonghua Lu Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study Emerging Microbes and Infections Helicobacter pylori recurrence reinfection risk factor epidemiology |
| title | Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study |
| title_full | Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study |
| title_fullStr | Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study |
| title_full_unstemmed | Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study |
| title_short | Long-term follow-up of Helicobacter pylori reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study |
| title_sort | long term follow up of helicobacter pylori reinfection and its risk factors after initial eradication a large scale multicentre prospective open cohort observational study |
| topic | Helicobacter pylori recurrence reinfection risk factor epidemiology |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1737579 |
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