SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins

SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins

Complement hyperactivation and thrombotic microangiopathy are closely associated with severe COVID-19. Endothelial dysfunction is a key mechanism underlying thrombotic microangiopathy. To address the relationship between endothelial injury, complement activation and thrombotic microangiopathy of sev...

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Bibliographic Details
Main Authors: Jian Wu, Sanpeng Xu, Zhiqing Li, Boyi Cong, Zongheng Yang, Zhichao Yang, Wanfeng Gao, Shuo Liu, Zhou Yu, Sheng Xu, Nan Li, Jin Hou, Guoping Wang, Xuetao Cao, Shuxun Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Thrombotic microangiopathy
-Endothelial cell
SARS-CoV-2
complement activation
complement regulatory protein
interferon
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2467781
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