Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female Physiology
The sleep–wake rhythm, regulated by the suprachiasmatic nucleus (SCN) and peripheral clocks, is influenced by light, nutrition, stress, and exercise. Recent findings suggest that estrogen receptors in the SCN may link ovarian hormone regulation to circadian rhythms, highlighting the need to consider...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Women |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4184/5/2/15 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849418280775712768 |
|---|---|
| author | Akemi Sawai Takashi Shida |
| author_facet | Akemi Sawai Takashi Shida |
| author_sort | Akemi Sawai |
| collection | DOAJ |
| description | The sleep–wake rhythm, regulated by the suprachiasmatic nucleus (SCN) and peripheral clocks, is influenced by light, nutrition, stress, and exercise. Recent findings suggest that estrogen receptors in the SCN may link ovarian hormone regulation to circadian rhythms, highlighting the need to consider hormonal fluctuations throughout the menstrual cycle when examining the effects of exercise on the sleep–wake rhythm in females. Therefore, we conducted a scoping review to compile existing studies involving human participants, aiming to provide a foundation for research focused on the specific physiological phenomena in females. Based on 228 literature sources, only 6 met the inclusion criteria. Despite variations in the exercise type, intensity, and duration, transient exercise demonstrated a significant impact on the expression of the clock genes BMAL1, PER2, and CRY1, suggesting their susceptibility to such activities. This review highlights the absence of studies examining the effects of exercise on clock gene expression in females, particularly in relation to menstrual cycles and ovarian hormone fluctuations, emphasizing the need for future investigations that incorporate these factors. |
| format | Article |
| id | doaj-art-909cd102cc7a47bca59c528fc32bb416 |
| institution | Kabale University |
| issn | 2673-4184 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Women |
| spelling | doaj-art-909cd102cc7a47bca59c528fc32bb4162025-08-20T03:32:28ZengMDPI AGWomen2673-41842025-04-01521510.3390/women5020015Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female PhysiologyAkemi Sawai0Takashi Shida1Department of Clinical Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 3058575, JapanResearch Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Tokyo 1730015, JapanThe sleep–wake rhythm, regulated by the suprachiasmatic nucleus (SCN) and peripheral clocks, is influenced by light, nutrition, stress, and exercise. Recent findings suggest that estrogen receptors in the SCN may link ovarian hormone regulation to circadian rhythms, highlighting the need to consider hormonal fluctuations throughout the menstrual cycle when examining the effects of exercise on the sleep–wake rhythm in females. Therefore, we conducted a scoping review to compile existing studies involving human participants, aiming to provide a foundation for research focused on the specific physiological phenomena in females. Based on 228 literature sources, only 6 met the inclusion criteria. Despite variations in the exercise type, intensity, and duration, transient exercise demonstrated a significant impact on the expression of the clock genes BMAL1, PER2, and CRY1, suggesting their susceptibility to such activities. This review highlights the absence of studies examining the effects of exercise on clock gene expression in females, particularly in relation to menstrual cycles and ovarian hormone fluctuations, emphasizing the need for future investigations that incorporate these factors.https://www.mdpi.com/2673-4184/5/2/15sleepcircadian rhythmclock gene expressionexercisesports |
| spellingShingle | Akemi Sawai Takashi Shida Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female Physiology Women sleep circadian rhythm clock gene expression exercise sports |
| title | Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female Physiology |
| title_full | Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female Physiology |
| title_fullStr | Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female Physiology |
| title_full_unstemmed | Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female Physiology |
| title_short | Impact of Acute Exercise Load on Clock Gene Expression: A Scoping Review of Human Studies with Implications for Female Physiology |
| title_sort | impact of acute exercise load on clock gene expression a scoping review of human studies with implications for female physiology |
| topic | sleep circadian rhythm clock gene expression exercise sports |
| url | https://www.mdpi.com/2673-4184/5/2/15 |
| work_keys_str_mv | AT akemisawai impactofacuteexerciseloadonclockgeneexpressionascopingreviewofhumanstudieswithimplicationsforfemalephysiology AT takashishida impactofacuteexerciseloadonclockgeneexpressionascopingreviewofhumanstudieswithimplicationsforfemalephysiology |