Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity
The human decidua is a specialized tissue characterized by embryo-receptive properties. It is formed during the secretory phase of menstrual cycle from uterine mucosa termed endometrium. The decidua is composed of glands, immune cells, blood and lymph vessels, and decidual stromal cells (DSCs). In t...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2016/8689436 |
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| author | Kameliya Vinketova Milena Mourdjeva Tsvetelina Oreshkova |
| author_facet | Kameliya Vinketova Milena Mourdjeva Tsvetelina Oreshkova |
| author_sort | Kameliya Vinketova |
| collection | DOAJ |
| description | The human decidua is a specialized tissue characterized by embryo-receptive properties. It is formed during the secretory phase of menstrual cycle from uterine mucosa termed endometrium. The decidua is composed of glands, immune cells, blood and lymph vessels, and decidual stromal cells (DSCs). In the process of decidualization, which is controlled by oestrogen and progesterone, DSCs acquire specific functions related to recognition, selection, and acceptance of the allogeneic embryo, as well as to development of maternal immune tolerance. In this review we discuss the relationship between the decidualization of DSCs and pathological obstetrical and gynaecological conditions. Moreover, the critical influence of DSCs on local immune cells populations as well as their relationship to the onset and maintenance of immune tolerance is described. |
| format | Article |
| id | doaj-art-9092be32dcf1466eb9bfcad2d78646b1 |
| institution | DOAJ |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-9092be32dcf1466eb9bfcad2d78646b12025-08-20T03:20:36ZengWileyJournal of Pregnancy2090-27272090-27352016-01-01201610.1155/2016/86894368689436Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal ImmunityKameliya Vinketova0Milena Mourdjeva1Tsvetelina Oreshkova2Department of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 73 Tsarigradsko Shose, 1113 Sofia, BulgariaDepartment of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 73 Tsarigradsko Shose, 1113 Sofia, BulgariaDepartment of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 73 Tsarigradsko Shose, 1113 Sofia, BulgariaThe human decidua is a specialized tissue characterized by embryo-receptive properties. It is formed during the secretory phase of menstrual cycle from uterine mucosa termed endometrium. The decidua is composed of glands, immune cells, blood and lymph vessels, and decidual stromal cells (DSCs). In the process of decidualization, which is controlled by oestrogen and progesterone, DSCs acquire specific functions related to recognition, selection, and acceptance of the allogeneic embryo, as well as to development of maternal immune tolerance. In this review we discuss the relationship between the decidualization of DSCs and pathological obstetrical and gynaecological conditions. Moreover, the critical influence of DSCs on local immune cells populations as well as their relationship to the onset and maintenance of immune tolerance is described.http://dx.doi.org/10.1155/2016/8689436 |
| spellingShingle | Kameliya Vinketova Milena Mourdjeva Tsvetelina Oreshkova Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity Journal of Pregnancy |
| title | Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity |
| title_full | Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity |
| title_fullStr | Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity |
| title_full_unstemmed | Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity |
| title_short | Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity |
| title_sort | human decidual stromal cells as a component of the implantation niche and a modulator of maternal immunity |
| url | http://dx.doi.org/10.1155/2016/8689436 |
| work_keys_str_mv | AT kameliyavinketova humandecidualstromalcellsasacomponentoftheimplantationnicheandamodulatorofmaternalimmunity AT milenamourdjeva humandecidualstromalcellsasacomponentoftheimplantationnicheandamodulatorofmaternalimmunity AT tsvetelinaoreshkova humandecidualstromalcellsasacomponentoftheimplantationnicheandamodulatorofmaternalimmunity |