Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung disease

Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung disease

Abstract Vaccines are central to the strategy to control antimicrobial resistant (AMR) bacterial infections; one multidrug resistant pathogen of particular concern is Acinetobacter baumannii. In this study we identified two novel A. baumannii antigens using mass spectrometry and phage expression: Ox...

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Bibliographic Details
Main Authors: Sophie L. Higham, Ziyin Wang, Valarmathy Murugaiah, Jihye Song, Chubicka Thomas, Houze Zhang, Uta Griesenbach, Eric W. F. W. Alton, Luke A. Granger, Andrea Flores Esparza, Beatriz Dias Barbieri, Paul G. Hitchen, Paul Kellam, Robin J. Shattock, Shiranee Sriskandan, Stephen T. Reece, John S. Tregoning
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01202-0
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