Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical Formulations
This research describes a new method for estimating tramadol hydrochloride in pharmaceutical formulations using Molecularly Imprinted Solid-Phase Extraction (MISPE) as a sample extraction technique. Acrylamide was used as the functional monomer, trimethylolpropane Trimethacrylate as the cross-linke...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2025-08-01
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| Series: | Journal of Engineering |
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| Online Access: | https://joe.uobaghdad.edu.iq/index.php/main/article/view/3676 |
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| author | Huda Hussein Ali Yehya Kamal Al-Bayati |
| author_facet | Huda Hussein Ali Yehya Kamal Al-Bayati |
| author_sort | Huda Hussein Ali |
| collection | DOAJ |
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This research describes a new method for estimating tramadol hydrochloride in pharmaceutical formulations using Molecularly Imprinted Solid-Phase Extraction (MISPE) as a sample extraction technique. Acrylamide was used as the functional monomer, trimethylolpropane Trimethacrylate as the cross-linker, and tramadol hydrochloride as the template molecule to make Molecularly Imprinted Polymer (MIP). The new molecularly imprinted polymer was characterized using UV-Vis spectroscopy, Fourier transform infrared spectroscopy, and a scanning electron microscope. The adsorption isotherm of the prepared polymer was determined under the optimum conditions using spectrophotometry at a wavelength of 272 nm. The method's linear dynamic range was found to be 5–140 µg/mL, and the limits of detection (LOD) and quantification (LOQ) were 0.62 and 1.87 µg/mL, respectively. Relative Standard Deviation (RSD%) was less than 2% five times in intra-day and inter-day. This method was successfully utilized to determine tramadol hydrochloride in pharmaceutical formulations with recoveries in the 93.04–104.3% range.
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| format | Article |
| id | doaj-art-9091f29488db4113ba6b8860f2fc76d4 |
| institution | Kabale University |
| issn | 1726-4073 2520-3339 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Journal of Engineering |
| spelling | doaj-art-9091f29488db4113ba6b8860f2fc76d42025-08-20T03:34:01ZengUniversity of BaghdadJournal of Engineering1726-40732520-33392025-08-0131810.31026/j.eng.2025.08.09Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical FormulationsHuda Hussein Ali0Yehya Kamal Al-Bayati 1Department of Chemistry, College of Science, University of BaghdadDepartment of Chemistry, College of Science, University of Baghdad This research describes a new method for estimating tramadol hydrochloride in pharmaceutical formulations using Molecularly Imprinted Solid-Phase Extraction (MISPE) as a sample extraction technique. Acrylamide was used as the functional monomer, trimethylolpropane Trimethacrylate as the cross-linker, and tramadol hydrochloride as the template molecule to make Molecularly Imprinted Polymer (MIP). The new molecularly imprinted polymer was characterized using UV-Vis spectroscopy, Fourier transform infrared spectroscopy, and a scanning electron microscope. The adsorption isotherm of the prepared polymer was determined under the optimum conditions using spectrophotometry at a wavelength of 272 nm. The method's linear dynamic range was found to be 5–140 µg/mL, and the limits of detection (LOD) and quantification (LOQ) were 0.62 and 1.87 µg/mL, respectively. Relative Standard Deviation (RSD%) was less than 2% five times in intra-day and inter-day. This method was successfully utilized to determine tramadol hydrochloride in pharmaceutical formulations with recoveries in the 93.04–104.3% range. https://joe.uobaghdad.edu.iq/index.php/main/article/view/3676Tramadol hydrochlorideMolecular imprinted polymerSolid-phase extractionAcrylamideTrimethylolpropane Trimethacrylate |
| spellingShingle | Huda Hussein Ali Yehya Kamal Al-Bayati Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical Formulations Journal of Engineering Tramadol hydrochloride Molecular imprinted polymer Solid-phase extraction Acrylamide Trimethylolpropane Trimethacrylate |
| title | Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical Formulations |
| title_full | Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical Formulations |
| title_fullStr | Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical Formulations |
| title_full_unstemmed | Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical Formulations |
| title_short | Design Molecular Imprinting Polymer Coupled with Spectrophotometric Detection for the Determination of Tramadol Hydrochloride in Pure and Pharmaceutical Formulations |
| title_sort | design molecular imprinting polymer coupled with spectrophotometric detection for the determination of tramadol hydrochloride in pure and pharmaceutical formulations |
| topic | Tramadol hydrochloride Molecular imprinted polymer Solid-phase extraction Acrylamide Trimethylolpropane Trimethacrylate |
| url | https://joe.uobaghdad.edu.iq/index.php/main/article/view/3676 |
| work_keys_str_mv | AT hudahusseinali designmolecularimprintingpolymercoupledwithspectrophotometricdetectionforthedeterminationoftramadolhydrochlorideinpureandpharmaceuticalformulations AT yehyakamalalbayati designmolecularimprintingpolymercoupledwithspectrophotometricdetectionforthedeterminationoftramadolhydrochlorideinpureandpharmaceuticalformulations |