DOCK2 protects against bacterial sepsis by constraining T helper 1 response

DOCK2 protects against bacterial sepsis by constraining T helper 1 response

BackgroundSepsis is a systemic host response to infection with life-threatening consequence which ranks among the top ten causes of death worldwide. Nevertheless, our understanding of the molecular and cellular impact of sepsis remains rudimentary.MethodsA mouse sepsis model was established through...

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Main Authors: Shusen Ye, Linzi Huang, Yuhao Zheng, Shanshan Liu, Xiangyang Wang, Haoyuan Yu, Lisi Zhu, Texi Liang, Yifei Wang, Chunmin Zhang, Fan Wu, Lilin Ye, Yingjiao Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
DOCK2
Th1
LPS
sepsis
E.coli
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527934/full
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