Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans
Protein glycosylation pathways are present in all kingdoms of life and are metabolic pathways found in all the life kingdoms. Despite sharing commonalities in their synthesis, glycans attached to glycoproteins have species-specific structures generated by the presence of different sets of enzymes an...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2014/267497 |
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| author | Iván Martínez-Duncker Diana F. Díaz-Jímenez Héctor M. Mora-Montes |
| author_facet | Iván Martínez-Duncker Diana F. Díaz-Jímenez Héctor M. Mora-Montes |
| author_sort | Iván Martínez-Duncker |
| collection | DOAJ |
| description | Protein glycosylation pathways are present in all kingdoms of life and are metabolic pathways found in all the life kingdoms. Despite sharing commonalities in their synthesis, glycans attached to glycoproteins have species-specific structures generated by the presence of different sets of enzymes and acceptor substrates in each organism. In this review, we present a comparative analysis of the main glycosylation pathways shared by humans and the fungal pathogen Candida albicans: N-linked glycosylation, O-linked mannosylation and glycosylphosphatidylinositol-anchorage. The knowledge of similarities and divergences between these metabolic pathways could help find new pharmacological targets for C. albicans infection. |
| format | Article |
| id | doaj-art-908a143b660e449e9a5b3f5c33bddea5 |
| institution | DOAJ |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-908a143b660e449e9a5b3f5c33bddea52025-08-20T03:20:30ZengWileyInternational Journal of Microbiology1687-918X1687-91982014-01-01201410.1155/2014/267497267497Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicansIván Martínez-Duncker0Diana F. Díaz-Jímenez1Héctor M. Mora-Montes2Laboratorio de Glicobiología Humana, Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, 62209 Cuernavaca, MOR, MexicoDepartamento de Ingeniería Genética, Centro de Investigaciones y Estudios Avanzados del IPN, 36821 Irapuato, GTO, MexicoDivisión de Ciencias Naturales y Exactas, Departamento de Biología, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Col. Noria Alta, 36050 Guanajuato, GTO, MexicoProtein glycosylation pathways are present in all kingdoms of life and are metabolic pathways found in all the life kingdoms. Despite sharing commonalities in their synthesis, glycans attached to glycoproteins have species-specific structures generated by the presence of different sets of enzymes and acceptor substrates in each organism. In this review, we present a comparative analysis of the main glycosylation pathways shared by humans and the fungal pathogen Candida albicans: N-linked glycosylation, O-linked mannosylation and glycosylphosphatidylinositol-anchorage. The knowledge of similarities and divergences between these metabolic pathways could help find new pharmacological targets for C. albicans infection.http://dx.doi.org/10.1155/2014/267497 |
| spellingShingle | Iván Martínez-Duncker Diana F. Díaz-Jímenez Héctor M. Mora-Montes Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans International Journal of Microbiology |
| title | Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans |
| title_full | Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans |
| title_fullStr | Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans |
| title_full_unstemmed | Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans |
| title_short | Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans |
| title_sort | comparative analysis of protein glycosylation pathways in humans and the fungal pathogen candida albicans |
| url | http://dx.doi.org/10.1155/2014/267497 |
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