TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation

TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation

Abstract After acute lesions in the central nervous system (CNS), the interaction of microglia, astrocytes, and infiltrating immune cells decides over their resolution or chronification. However, this CNS-intrinsic cross-talk is poorly characterized. Analyzing cerebrospinal fluid (CSF) samples of Mu...

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Main Authors: Lena Lößlein, Mathias Linnerbauer, Finnja Zuber, Thanos Tsaktanis, Oliver Vandrey, Anne Peter, Franziska Panier, Julia Zissler, Vivienne Riekher, Tobias Bäuerle, Jannis Hanspach, Frederik B. Laun, Lisa Nagel, Lisa Mészáros, Friederike Zunke, Jürgen Winkler, Ulrike J. Naumann, Nora Schwingen, Emely Neumaier, Arthur Liesz, Francisco Quintana, Veit Rothhammer
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60363-7
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