Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice
Abstract Acute lung injury (ALI) is the result of damage to the capillary endothelia and the alveolar epithelial cell caused by various direct and indirect factors, leading to significant pulmonary interstitial and alveolar edema and acute hypoxic respiratory insufficiency. A subset of ALI cases pro...
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| Language: | English |
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BMC
2024-09-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-024-03273-6 |
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| author | Tongtong Xue Qianyi Zhang Tiantian Zhang Lingxin Meng Jing Liu Dan Chai Yuming Liu Zhongyi Yang Ran Jiao Yunyao Cui Jingjing Gao Xiaohe Li Aiguo Xu Honggang Zhou |
| author_facet | Tongtong Xue Qianyi Zhang Tiantian Zhang Lingxin Meng Jing Liu Dan Chai Yuming Liu Zhongyi Yang Ran Jiao Yunyao Cui Jingjing Gao Xiaohe Li Aiguo Xu Honggang Zhou |
| author_sort | Tongtong Xue |
| collection | DOAJ |
| description | Abstract Acute lung injury (ALI) is the result of damage to the capillary endothelia and the alveolar epithelial cell caused by various direct and indirect factors, leading to significant pulmonary interstitial and alveolar edema and acute hypoxic respiratory insufficiency. A subset of ALI cases progresses to irreversible pulmonary fibrosis, a condition with fatal implications. Zafirlukast is a leukotriene receptor antagonist licensed for asthma prevention and long-term treatment. This study demonstrated a significant improvement in lung tissue pathology and a reduction in inflammatory cell infiltration in models of lipopolysaccharide (LPS)-induced ALI and bleomycin (BLM)-induced lung inflammation following zafirlukast administration, both in vivo and in vitro. Moreover, zafirlukast was found to suppress the inflammatory response of alveolar epithelial cells in vitro and lung inflammation in vivo by reducing the activation of the TLR4/NF-κB/NLRP3 inflammasome pathway. In conclusion, zafirlukast relieved lung injury and the infiltration of inflammatory cells in the lung by regulating the TLR4/NF-κB/NLRP3 pathway. |
| format | Article |
| id | doaj-art-9086ce84774b4ff080b8ab6f44bcddc4 |
| institution | DOAJ |
| issn | 1471-2466 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-9086ce84774b4ff080b8ab6f44bcddc42025-08-20T03:06:48ZengBMCBMC Pulmonary Medicine1471-24662024-09-0124111510.1186/s12890-024-03273-6Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in miceTongtong Xue0Qianyi Zhang1Tiantian Zhang2Lingxin Meng3Jing Liu4Dan Chai5Yuming Liu6Zhongyi Yang7Ran Jiao8Yunyao Cui9Jingjing Gao10Xiaohe Li11Aiguo Xu12Honggang Zhou13Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityTianjin Jikun Technology Co., LtdTianjin Jikun Technology Co., LtdState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai UniversityAbstract Acute lung injury (ALI) is the result of damage to the capillary endothelia and the alveolar epithelial cell caused by various direct and indirect factors, leading to significant pulmonary interstitial and alveolar edema and acute hypoxic respiratory insufficiency. A subset of ALI cases progresses to irreversible pulmonary fibrosis, a condition with fatal implications. Zafirlukast is a leukotriene receptor antagonist licensed for asthma prevention and long-term treatment. This study demonstrated a significant improvement in lung tissue pathology and a reduction in inflammatory cell infiltration in models of lipopolysaccharide (LPS)-induced ALI and bleomycin (BLM)-induced lung inflammation following zafirlukast administration, both in vivo and in vitro. Moreover, zafirlukast was found to suppress the inflammatory response of alveolar epithelial cells in vitro and lung inflammation in vivo by reducing the activation of the TLR4/NF-κB/NLRP3 inflammasome pathway. In conclusion, zafirlukast relieved lung injury and the infiltration of inflammatory cells in the lung by regulating the TLR4/NF-κB/NLRP3 pathway.https://doi.org/10.1186/s12890-024-03273-6ZafirlukastAcute lung injuryEpithelial cellNF-κB |
| spellingShingle | Tongtong Xue Qianyi Zhang Tiantian Zhang Lingxin Meng Jing Liu Dan Chai Yuming Liu Zhongyi Yang Ran Jiao Yunyao Cui Jingjing Gao Xiaohe Li Aiguo Xu Honggang Zhou Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice BMC Pulmonary Medicine Zafirlukast Acute lung injury Epithelial cell NF-κB |
| title | Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice |
| title_full | Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice |
| title_fullStr | Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice |
| title_full_unstemmed | Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice |
| title_short | Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice |
| title_sort | zafirlukast ameliorates lipopolysaccharide and bleomycin induced lung inflammation in mice |
| topic | Zafirlukast Acute lung injury Epithelial cell NF-κB |
| url | https://doi.org/10.1186/s12890-024-03273-6 |
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