Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands
Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types. Case 1. A 70-year-old man. Radiologic...
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/9130754 |
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| author | Takashi Miyata Katsuhiko Uesaka Yasuni Nakanuma |
| author_facet | Takashi Miyata Katsuhiko Uesaka Yasuni Nakanuma |
| author_sort | Takashi Miyata |
| collection | DOAJ |
| description | Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types. Case 1. A 70-year-old man. Radiologically, a cystic tumor measuring 20 mm in diameter was found at the hepatic hilum. Right hepatectomy was performed under a diagnosis of intrahepatic cholangiocarcinoma (iCCA) based on the imaging findings. Case 2. A 70-year-old man. Radiologically, a cystic tumor measuring 60 mm in diameter was found at the hepatic hilum. Under a diagnosis of iCCA, left hepatic trisectionectomy was performed. In both cases, endoscopic retrograde cholangiography did not demonstrate communication between the cystic tumor and adjacent bile ducts. Pathologically, these two tumors were cystic neoplasms located at the hepatic hilum and were morphologically characterized by an intracystic papillary neoplasm composed of diffuse high-grade dysplasia and associated with an invasive carcinoma. Ovarian-like stroma was not found in the capsule of these tumors. Interestingly, there were peribiliary glands near these tumors, and MUC6 was expressed in these papillary neoplasms as well as in the peribiliary glands. These neoplasms might have arisen from the peribiliary glands. |
| format | Article |
| id | doaj-art-908660b9ef904bbbafc831be8994d1fb |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Case Reports in Pathology |
| spelling | doaj-art-908660b9ef904bbbafc831be8994d1fb2025-08-20T02:09:14ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/91307549130754Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary GlandsTakashi Miyata0Katsuhiko Uesaka1Yasuni Nakanuma2Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, JapanDivision of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, JapanDivision of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, JapanCystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types. Case 1. A 70-year-old man. Radiologically, a cystic tumor measuring 20 mm in diameter was found at the hepatic hilum. Right hepatectomy was performed under a diagnosis of intrahepatic cholangiocarcinoma (iCCA) based on the imaging findings. Case 2. A 70-year-old man. Radiologically, a cystic tumor measuring 60 mm in diameter was found at the hepatic hilum. Under a diagnosis of iCCA, left hepatic trisectionectomy was performed. In both cases, endoscopic retrograde cholangiography did not demonstrate communication between the cystic tumor and adjacent bile ducts. Pathologically, these two tumors were cystic neoplasms located at the hepatic hilum and were morphologically characterized by an intracystic papillary neoplasm composed of diffuse high-grade dysplasia and associated with an invasive carcinoma. Ovarian-like stroma was not found in the capsule of these tumors. Interestingly, there were peribiliary glands near these tumors, and MUC6 was expressed in these papillary neoplasms as well as in the peribiliary glands. These neoplasms might have arisen from the peribiliary glands.http://dx.doi.org/10.1155/2016/9130754 |
| spellingShingle | Takashi Miyata Katsuhiko Uesaka Yasuni Nakanuma Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands Case Reports in Pathology |
| title | Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands |
| title_full | Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands |
| title_fullStr | Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands |
| title_full_unstemmed | Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands |
| title_short | Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands |
| title_sort | cystic and papillary neoplasm at the hepatic hilum possibly originating in the peribiliary glands |
| url | http://dx.doi.org/10.1155/2016/9130754 |
| work_keys_str_mv | AT takashimiyata cysticandpapillaryneoplasmatthehepatichilumpossiblyoriginatingintheperibiliaryglands AT katsuhikouesaka cysticandpapillaryneoplasmatthehepatichilumpossiblyoriginatingintheperibiliaryglands AT yasuninakanuma cysticandpapillaryneoplasmatthehepatichilumpossiblyoriginatingintheperibiliaryglands |