Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature
A 65-year-old male with a history of ischemic strokes, seizures, and subarachnoid hemorrhage presented with a 4-week history of progressive diplopia, vertigo, nausea, and vomiting. Magnetic resonance imaging (MRI) revealed a 2.5×1.8×1.7 cm posterior fossa mass arising from the roof of the 4th ventri...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/2671794 |
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| author | Ava Brozovich Donald Ewing Ethan Burns Courtney Hatcher Gonzalo Acosta Usman Khan Betty Chung Leena Samuel Jasleen Randhawa Sai Ravi Pingali |
| author_facet | Ava Brozovich Donald Ewing Ethan Burns Courtney Hatcher Gonzalo Acosta Usman Khan Betty Chung Leena Samuel Jasleen Randhawa Sai Ravi Pingali |
| author_sort | Ava Brozovich |
| collection | DOAJ |
| description | A 65-year-old male with a history of ischemic strokes, seizures, and subarachnoid hemorrhage presented with a 4-week history of progressive diplopia, vertigo, nausea, and vomiting. Magnetic resonance imaging (MRI) revealed a 2.5×1.8×1.7 cm posterior fossa mass arising from the roof of the 4th ventricle extending into the cerebellar vermis. Posterior fossa craniotomy with stereotactic biopsy confirmed a locally invasive diffuse large B-cell lymphoma (DLBCL). Primary central nervous system lymphoma (PCNSL) arising from the 4th ventricle is a rare extranodal manifestation of non-Hodgkin lymphoma (NHL), with few cases documented in the literature. Review of available cases lends support that lymphoma arising from the 4th ventricle has a variable clinical presentation, occurs most commonly in immunocompetent males, and should be on the differential of any immunocompetent adult presenting with a posterior fossa mass. Optimal treatment modalities are based largely on phase 2 clinical trials, and recommended guidelines regardless of anatomic location should be adhered to. |
| format | Article |
| id | doaj-art-90831d16b3754ef1b6ba5b391d0adf9a |
| institution | DOAJ |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-90831d16b3754ef1b6ba5b391d0adf9a2025-08-20T03:20:30ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/26717942671794Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the LiteratureAva Brozovich0Donald Ewing1Ethan Burns2Courtney Hatcher3Gonzalo Acosta4Usman Khan5Betty Chung6Leena Samuel7Jasleen Randhawa8Sai Ravi Pingali9Texas A&M University College of Medicine, 8441 Riverside Parkway, Bryan, TX 77807, USATexas A&M University College of Medicine, 8441 Riverside Parkway, Bryan, TX 77807, USAHouston Methodist Hospital, Department of Medicine, 6550 Fannin St., Houston, TX 77030, USAHouston Methodist Hospital, Department of Medicine, 6550 Fannin St., Houston, TX 77030, USAHouston Methodist Hospital, Department of Medicine, 6550 Fannin St., Houston, TX 77030, USAHouston Methodist Hospital, Department of Medicine, 6550 Fannin St., Houston, TX 77030, USAHouston Methodist Hospital, Department of Pathology and Genomic Medicine, 6550 Fannin St., Houston, TX 77030, USAHouston Methodist Hospital, Department of Medicine, 6550 Fannin St., Houston, TX 77030, USAHouston Methodist Hospital, Department of Medicine, 6550 Fannin St., Houston, TX 77030, USAHouston Methodist Hospital, Department of Medicine, 6550 Fannin St., Houston, TX 77030, USAA 65-year-old male with a history of ischemic strokes, seizures, and subarachnoid hemorrhage presented with a 4-week history of progressive diplopia, vertigo, nausea, and vomiting. Magnetic resonance imaging (MRI) revealed a 2.5×1.8×1.7 cm posterior fossa mass arising from the roof of the 4th ventricle extending into the cerebellar vermis. Posterior fossa craniotomy with stereotactic biopsy confirmed a locally invasive diffuse large B-cell lymphoma (DLBCL). Primary central nervous system lymphoma (PCNSL) arising from the 4th ventricle is a rare extranodal manifestation of non-Hodgkin lymphoma (NHL), with few cases documented in the literature. Review of available cases lends support that lymphoma arising from the 4th ventricle has a variable clinical presentation, occurs most commonly in immunocompetent males, and should be on the differential of any immunocompetent adult presenting with a posterior fossa mass. Optimal treatment modalities are based largely on phase 2 clinical trials, and recommended guidelines regardless of anatomic location should be adhered to.http://dx.doi.org/10.1155/2019/2671794 |
| spellingShingle | Ava Brozovich Donald Ewing Ethan Burns Courtney Hatcher Gonzalo Acosta Usman Khan Betty Chung Leena Samuel Jasleen Randhawa Sai Ravi Pingali Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature |
| title_full | Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature |
| title_fullStr | Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature |
| title_full_unstemmed | Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature |
| title_short | Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature |
| title_sort | primary cns lymphoma arising from the 4th ventricle a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2019/2671794 |
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