Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects

Damage to the articular cartilage of the tibial plateau presents significant challenges, resulting in pain, functional impairment, and progressive joint degeneration that can lead to severe osteoarthritis. Traditional open surgeries, although effective, are associated with substantial tissue disrupt...

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Main Authors: Domenico Franco, M.D., Chilan B.G. Leite, M.D., Ph.D., Sebastian Schmidt, M.D., Nathan Sherman, M.D., Omar Protzuk, M.D., Christian Lattermann, M.D.
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Arthroscopy Techniques
Online Access:http://www.sciencedirect.com/science/article/pii/S2212628725001148
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author Domenico Franco, M.D.
Chilan B.G. Leite, M.D., Ph.D.
Sebastian Schmidt, M.D.
Nathan Sherman, M.D.
Omar Protzuk, M.D.
Christian Lattermann, M.D.
author_facet Domenico Franco, M.D.
Chilan B.G. Leite, M.D., Ph.D.
Sebastian Schmidt, M.D.
Nathan Sherman, M.D.
Omar Protzuk, M.D.
Christian Lattermann, M.D.
author_sort Domenico Franco, M.D.
collection DOAJ
description Damage to the articular cartilage of the tibial plateau presents significant challenges, resulting in pain, functional impairment, and progressive joint degeneration that can lead to severe osteoarthritis. Traditional open surgeries, although effective, are associated with substantial tissue disruption, prolonged recovery, and risks of complications. Here, we present an arthroscopic technique for matrix-associated autologous chondrocyte implantation tailored to address focal tibial cartilage defects. This technique integrates meticulous arthroscopic preparation of the defect site and precise implantation of the matrix-associated autologous chondrocyte implantation membrane. The postoperative protocol emphasizes gradual weight-bearing and progressive functional recovery, enabling a safe return to daily activities and sports.
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series Arthroscopy Techniques
spelling doaj-art-907c6bcedf8b4d0d9841cc989f8509652025-08-20T03:32:01ZengElsevierArthroscopy Techniques2212-62872025-06-0114610354510.1016/j.eats.2025.103545Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial DefectsDomenico Franco, M.D.0Chilan B.G. Leite, M.D., Ph.D.1Sebastian Schmidt, M.D.2Nathan Sherman, M.D.3Omar Protzuk, M.D.4Christian Lattermann, M.D.5Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.; Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Address correspondence to Domenico Franco, M.D., Via Kennedy 9, Altomonte (CS) – Italy.Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.; Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.Damage to the articular cartilage of the tibial plateau presents significant challenges, resulting in pain, functional impairment, and progressive joint degeneration that can lead to severe osteoarthritis. Traditional open surgeries, although effective, are associated with substantial tissue disruption, prolonged recovery, and risks of complications. Here, we present an arthroscopic technique for matrix-associated autologous chondrocyte implantation tailored to address focal tibial cartilage defects. This technique integrates meticulous arthroscopic preparation of the defect site and precise implantation of the matrix-associated autologous chondrocyte implantation membrane. The postoperative protocol emphasizes gradual weight-bearing and progressive functional recovery, enabling a safe return to daily activities and sports.http://www.sciencedirect.com/science/article/pii/S2212628725001148
spellingShingle Domenico Franco, M.D.
Chilan B.G. Leite, M.D., Ph.D.
Sebastian Schmidt, M.D.
Nathan Sherman, M.D.
Omar Protzuk, M.D.
Christian Lattermann, M.D.
Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects
Arthroscopy Techniques
title Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects
title_full Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects
title_fullStr Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects
title_full_unstemmed Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects
title_short Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects
title_sort arthroscopic matrix associated autologous chondrocyte implantation for focal tibial defects
url http://www.sciencedirect.com/science/article/pii/S2212628725001148
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