Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma
Retroperitoneal liposarcoma, especially dedifferentiated liposarcoma (DDL), is a rare tumor type primarily affecting middle-aged and older adults in the retroperitoneum or proximal extremities. This case report highlights an exceptionally large retroperitoneal DDL that had enveloped the entire right...
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| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1489833/full |
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| author | Huey Bing Chua Rizuana Iqbal Hussain Nordashima Abd Shukor Xeng Inn Fam |
| author_facet | Huey Bing Chua Rizuana Iqbal Hussain Nordashima Abd Shukor Xeng Inn Fam |
| author_sort | Huey Bing Chua |
| collection | DOAJ |
| description | Retroperitoneal liposarcoma, especially dedifferentiated liposarcoma (DDL), is a rare tumor type primarily affecting middle-aged and older adults in the retroperitoneum or proximal extremities. This case report highlights an exceptionally large retroperitoneal DDL that had enveloped the entire right kidney and had adhered to nearby tissues. Diagnosing retroperitoneal liposarcoma is challenging due to its asymptomatic nature until it reaches a substantial size. Imaging, particularly contrast-enhanced computed tomography (CECT), play a vital role in diagnosis, staging, and preoperative planning. Surgical resection, with the goal of R0 resection, remains the cornerstone of treatment, albeit this can be challenging due to tumor location. First-line treatment for advanced DDL involves anthracycline-based therapy. Eribulin and pazopanib show promise in second-line treatment. Ongoing clinical trials suggest a shift towards multimodal therapy. This case report reports the largest retroperitoneal liposarcoma and underscores the complexity of managing retroperitoneal DDL. |
| format | Article |
| id | doaj-art-90753563bf7e4a768910dd7e1da8e5a2 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-90753563bf7e4a768910dd7e1da8e5a22025-08-20T02:56:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.14898331489833Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcomaHuey Bing Chua0Rizuana Iqbal Hussain1Nordashima Abd Shukor2Xeng Inn Fam3Urology Unit, Department of Surgery, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaUrology Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaRetroperitoneal liposarcoma, especially dedifferentiated liposarcoma (DDL), is a rare tumor type primarily affecting middle-aged and older adults in the retroperitoneum or proximal extremities. This case report highlights an exceptionally large retroperitoneal DDL that had enveloped the entire right kidney and had adhered to nearby tissues. Diagnosing retroperitoneal liposarcoma is challenging due to its asymptomatic nature until it reaches a substantial size. Imaging, particularly contrast-enhanced computed tomography (CECT), play a vital role in diagnosis, staging, and preoperative planning. Surgical resection, with the goal of R0 resection, remains the cornerstone of treatment, albeit this can be challenging due to tumor location. First-line treatment for advanced DDL involves anthracycline-based therapy. Eribulin and pazopanib show promise in second-line treatment. Ongoing clinical trials suggest a shift towards multimodal therapy. This case report reports the largest retroperitoneal liposarcoma and underscores the complexity of managing retroperitoneal DDL.https://www.frontiersin.org/articles/10.3389/fonc.2025.1489833/fullliposarcomarenalretroperitoneumsurgerycase reports |
| spellingShingle | Huey Bing Chua Rizuana Iqbal Hussain Nordashima Abd Shukor Xeng Inn Fam Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma Frontiers in Oncology liposarcoma renal retroperitoneum surgery case reports |
| title | Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma |
| title_full | Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma |
| title_fullStr | Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma |
| title_full_unstemmed | Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma |
| title_short | Case Report: an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma |
| title_sort | case report an extremely rare case of giant dedifferentiated retroperitoneal liposarcoma |
| topic | liposarcoma renal retroperitoneum surgery case reports |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1489833/full |
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