Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms
Type B aortic dissection (TBAD) represents a serious medical emergency with up to a 50% associated 5-year mortality caused by thoracic aorta, dissection-associated aneurysmal (DAA) degeneration, and rupture. Unfortunately, conventional size-related diagnostic methods cannot distinguish high-risk DAA...
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| Format: | Article |
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Elsevier
2025-04-01
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| Series: | Journal of Vascular Surgery Cases and Innovative Techniques |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468428724002818 |
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| author | Adnan Hirad, MD, PhD Faisal S. Fakhouri, PhD Brian Raterman, BS Ronald Lakony, BS Maxwell Wang, MD Dakota Gonring, MD Baqir Kedwai, MD Arunark Kolipaka, PhD Doran Mix, MD |
| author_facet | Adnan Hirad, MD, PhD Faisal S. Fakhouri, PhD Brian Raterman, BS Ronald Lakony, BS Maxwell Wang, MD Dakota Gonring, MD Baqir Kedwai, MD Arunark Kolipaka, PhD Doran Mix, MD |
| author_sort | Adnan Hirad, MD, PhD |
| collection | DOAJ |
| description | Type B aortic dissection (TBAD) represents a serious medical emergency with up to a 50% associated 5-year mortality caused by thoracic aorta, dissection-associated aneurysmal (DAA) degeneration, and rupture. Unfortunately, conventional size-related diagnostic methods cannot distinguish high-risk DAAs that benefit from surgical intervention from stable DAAs. Our goal is to use DAA stiffness measured with magnetic resonance elastography (MRE) as a biomarker to distinguish high-risk DAAs from stable DAAs. This is a feasibility study using MRE to (1) fabricate human-like geometries TBAD phantoms with different stiffnesses, (2) measure stiffness in TBAD phantoms with rheometry, and (3) demonstrate the first successful application of MRE to the thoracic aorta of a human volunteer. AD phantoms with heterogenous wall stiffness demonstrated the correlation between MRE-derived stiffness and rheometric measured stiffness. A pilot scan was performed in a healthy volunteer to test the technique's feasibility in the thoracic aorta. |
| format | Article |
| id | doaj-art-90740d96bb6d4085aa3a1c463916a3e7 |
| institution | OA Journals |
| issn | 2468-4287 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Vascular Surgery Cases and Innovative Techniques |
| spelling | doaj-art-90740d96bb6d4085aa3a1c463916a3e72025-08-20T01:57:39ZengElsevierJournal of Vascular Surgery Cases and Innovative Techniques2468-42872025-04-0111210169710.1016/j.jvscit.2024.101697Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantomsAdnan Hirad, MD, PhD0Faisal S. Fakhouri, PhD1Brian Raterman, BS2Ronald Lakony, BS3Maxwell Wang, MD4Dakota Gonring, MD5Baqir Kedwai, MD6Arunark Kolipaka, PhD7Doran Mix, MD8Department of Surgery, University of Rochester School of Medicine, Rochester, NYDepartment of Biomedical Technology, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi ArabiaDepartment of Radiology, The Ohio State University, Wexner Medical Center, Columbus, OHDepartment of Surgery, University of Rochester School of Medicine, Rochester, NYDivision of Vascular Surgery, Loma Linda University Health Medical Center, Loma Linda, CADepartment of Surgery, University of Rochester School of Medicine, Rochester, NYDepartment of Surgery, University of Rochester School of Medicine, Rochester, NYDepartment of Radiology, The Ohio State University, Wexner Medical Center, Columbus, OHDepartment of Surgery, University of Rochester School of Medicine, Rochester, NY; Correspondence: Doran Mix, MD, Department of Surgery, University of Rochester School of Medicine, 601 Elmwood Ave, Box 652, Rochester, NY 14642Type B aortic dissection (TBAD) represents a serious medical emergency with up to a 50% associated 5-year mortality caused by thoracic aorta, dissection-associated aneurysmal (DAA) degeneration, and rupture. Unfortunately, conventional size-related diagnostic methods cannot distinguish high-risk DAAs that benefit from surgical intervention from stable DAAs. Our goal is to use DAA stiffness measured with magnetic resonance elastography (MRE) as a biomarker to distinguish high-risk DAAs from stable DAAs. This is a feasibility study using MRE to (1) fabricate human-like geometries TBAD phantoms with different stiffnesses, (2) measure stiffness in TBAD phantoms with rheometry, and (3) demonstrate the first successful application of MRE to the thoracic aorta of a human volunteer. AD phantoms with heterogenous wall stiffness demonstrated the correlation between MRE-derived stiffness and rheometric measured stiffness. A pilot scan was performed in a healthy volunteer to test the technique's feasibility in the thoracic aorta.http://www.sciencedirect.com/science/article/pii/S2468428724002818Magnetic resonance elastographyAortic biomechanicsAortic dissectionThoracic aortic stiffness |
| spellingShingle | Adnan Hirad, MD, PhD Faisal S. Fakhouri, PhD Brian Raterman, BS Ronald Lakony, BS Maxwell Wang, MD Dakota Gonring, MD Baqir Kedwai, MD Arunark Kolipaka, PhD Doran Mix, MD Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms Journal of Vascular Surgery Cases and Innovative Techniques Magnetic resonance elastography Aortic biomechanics Aortic dissection Thoracic aortic stiffness |
| title | Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms |
| title_full | Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms |
| title_fullStr | Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms |
| title_full_unstemmed | Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms |
| title_short | Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms |
| title_sort | feasibility of measuring magnetic resonance elastography derived stiffness in human thoracic aorta and aortic dissection phantoms |
| topic | Magnetic resonance elastography Aortic biomechanics Aortic dissection Thoracic aortic stiffness |
| url | http://www.sciencedirect.com/science/article/pii/S2468428724002818 |
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