Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.)

Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.)

BackgroundProcessed Aconiti Kusnezoffii Radix (Aconiti kusnezoffii Radix Preparata, Zhicaowu) and Terminalia chebula Retz. (Hezi) are a classic herb pair in Mongolian medicine, where Hezi mitigates Zhicaowu’s hepatotoxicity. Despite extensive studies on their detoxification effects, the role of cyto...

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Bibliographic Details
Main Authors: Junxuan Zhu, Ming An, Weiting Wang, Jingjing Guo, Mengting Chen, Longlong Fang, Cen Wang, Dong Zhang, Guodong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Aconiti kusnezoffii Radix Preparata
Terminalia chebula Retz.
cocktail probe drug method
CYP450
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1573739/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1573739/full

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