Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review
ObjectiveElizabethkingia miricola is a rarely encountered pathogen in clinical settings, predominantly causing infections in immunocompromised individuals. To advance the understanding of E. miricola infection, we present a case of E. miricola infection and conduct a literature review.MethodsWe repo...
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| Format: | Article |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1561379/full |
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| author | Xiaoxiao Mao Xiaoxiao Mao Xiao Feng Chaoyang Li Xiupeng Xu Lin Zhao Jia Xu Liqing Bi Liqing Bi Zhen Yue Zhen Yue |
| author_facet | Xiaoxiao Mao Xiaoxiao Mao Xiao Feng Chaoyang Li Xiupeng Xu Lin Zhao Jia Xu Liqing Bi Liqing Bi Zhen Yue Zhen Yue |
| author_sort | Xiaoxiao Mao |
| collection | DOAJ |
| description | ObjectiveElizabethkingia miricola is a rarely encountered pathogen in clinical settings, predominantly causing infections in immunocompromised individuals. To advance the understanding of E. miricola infection, we present a case of E. miricola infection and conduct a literature review.MethodsWe report a case of pulmonary infection caused by E. miricola in a 90-year-old trauma patient, marking the first documented instance of treatment with eravacycline. We also conducted a systematic review of the relevant literature. A comprehensive search was performed using the PubMed and Web of Science databases up to November 2024. A qualitative synthesis was conducted on all available case reports and case series related to E. miricola infections.ResultsA total of 63 cases from 21 studies were included in this systematic review. According to these case reports, infections caused by E. miricola most commonly occur in the lungs (34/63), bloodstream (6/63), and urinary tract (4/63). Risk factors for E. miricola infection include immunodeficiency, prolonged hospitalization in the intensive care unit (ICU), prolonged mechanical ventilation, and the use of broad-spectrum antibiotics. Notably, a considerable proportion of cases (17/63) are hospital-acquired.ConclusionElizabethkingia miricola represents a rare but highly lethal opportunistic pathogen. Early identification and treatment with sensitive antibiotics are required to improve the prognosis of patients. The present case and literature review provide options for the diagnosis and treatment of similar cases in the future and serve as a reference for preventing and controlling the occurrence and spread of nosocomial infections.Systematic review registrationhttps://pubmed.ncbi.nlm.nih.gov/, https://www.webofscience.com/wos/. |
| format | Article |
| id | doaj-art-906e73c0f34d4bd8a1f9ef0ffbb26c18 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-906e73c0f34d4bd8a1f9ef0ffbb26c182025-08-20T02:16:02ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-05-011210.3389/fmed.2025.15613791561379Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature reviewXiaoxiao Mao0Xiaoxiao Mao1Xiao Feng2Chaoyang Li3Xiupeng Xu4Lin Zhao5Jia Xu6Liqing Bi7Liqing Bi8Zhen Yue9Zhen Yue10Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Pathology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaObjectiveElizabethkingia miricola is a rarely encountered pathogen in clinical settings, predominantly causing infections in immunocompromised individuals. To advance the understanding of E. miricola infection, we present a case of E. miricola infection and conduct a literature review.MethodsWe report a case of pulmonary infection caused by E. miricola in a 90-year-old trauma patient, marking the first documented instance of treatment with eravacycline. We also conducted a systematic review of the relevant literature. A comprehensive search was performed using the PubMed and Web of Science databases up to November 2024. A qualitative synthesis was conducted on all available case reports and case series related to E. miricola infections.ResultsA total of 63 cases from 21 studies were included in this systematic review. According to these case reports, infections caused by E. miricola most commonly occur in the lungs (34/63), bloodstream (6/63), and urinary tract (4/63). Risk factors for E. miricola infection include immunodeficiency, prolonged hospitalization in the intensive care unit (ICU), prolonged mechanical ventilation, and the use of broad-spectrum antibiotics. Notably, a considerable proportion of cases (17/63) are hospital-acquired.ConclusionElizabethkingia miricola represents a rare but highly lethal opportunistic pathogen. Early identification and treatment with sensitive antibiotics are required to improve the prognosis of patients. The present case and literature review provide options for the diagnosis and treatment of similar cases in the future and serve as a reference for preventing and controlling the occurrence and spread of nosocomial infections.Systematic review registrationhttps://pubmed.ncbi.nlm.nih.gov/, https://www.webofscience.com/wos/.https://www.frontiersin.org/articles/10.3389/fmed.2025.1561379/fullElizabethkingia miricolapulmonary infectionseptic shockcase reportsystematic review |
| spellingShingle | Xiaoxiao Mao Xiaoxiao Mao Xiao Feng Chaoyang Li Xiupeng Xu Lin Zhao Jia Xu Liqing Bi Liqing Bi Zhen Yue Zhen Yue Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review Frontiers in Medicine Elizabethkingia miricola pulmonary infection septic shock case report systematic review |
| title | Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review |
| title_full | Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review |
| title_fullStr | Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review |
| title_full_unstemmed | Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review |
| title_short | Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review |
| title_sort | septic shock caused by elizabethkingia miricola in an elderly trauma patient a case report and systematic literature review |
| topic | Elizabethkingia miricola pulmonary infection septic shock case report systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1561379/full |
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