Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota
Nephrotic syndrome (NS) represents a prevalent syndrome among various chronic kidney disease pathologies and is known for its higher severity and worse prognosis compared with chronic glomerulonephritis. Understanding its pathogenesis and identifying more effective treatment modalities have long bee...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1430356/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850138143983927296 |
|---|---|
| author | Jing Li Yupei Xu Tianhao Sun Xiaotian Zhang Huimin Liang Wei Lin Hangxing Yu Bo Yang Hongtao Yang |
| author_facet | Jing Li Yupei Xu Tianhao Sun Xiaotian Zhang Huimin Liang Wei Lin Hangxing Yu Bo Yang Hongtao Yang |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Nephrotic syndrome (NS) represents a prevalent syndrome among various chronic kidney disease pathologies and is known for its higher severity and worse prognosis compared with chronic glomerulonephritis. Understanding its pathogenesis and identifying more effective treatment modalities have long been a concern of kidney specialists. With the introduction of the gut–kidney axis concept and the progress in omics technologies, alterations in the gut microbiota have been observed in primary and secondary NS. This link has been extensively researched in conditions such as diabetic nephropathy and immunoglobulin A (IgA) nephropathy. Thus, dysbiosis of the gut microbiota is seen as a crucial contributing factor in NS; however, there is a lack of comprehensive reviews that elucidate the changes in the gut microbiota across different NS conditions and that describe its mechanistic role in the disease. Moreover, serving as an innate regulator of the gut microbiota, traditional Chinese medicine (TCM) has the potential to exert a profound impact on the expression of inflammation-promoting agents, decreasing the levels of endotoxins and uremic toxins. In addition, it strengthens the stability of the intestinal barrier while controlling the metabolic function of the body through its efficient modulation of the gut microbiota. This intricate process yields far-reaching consequences for NS. |
| format | Article |
| id | doaj-art-906e4b00dd1b472fb8dad0aa38981b3f |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-906e4b00dd1b472fb8dad0aa38981b3f2025-08-20T02:30:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14303561430356Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiotaJing Li0Yupei Xu1Tianhao Sun2Xiaotian Zhang3Huimin Liang4Wei Lin5Hangxing Yu6Bo Yang7Hongtao Yang8Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Nephrology, Traditional Chinese Hospital of Xiamen, Xiamen, ChinaDepartment of Nephrology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaNephrotic syndrome (NS) represents a prevalent syndrome among various chronic kidney disease pathologies and is known for its higher severity and worse prognosis compared with chronic glomerulonephritis. Understanding its pathogenesis and identifying more effective treatment modalities have long been a concern of kidney specialists. With the introduction of the gut–kidney axis concept and the progress in omics technologies, alterations in the gut microbiota have been observed in primary and secondary NS. This link has been extensively researched in conditions such as diabetic nephropathy and immunoglobulin A (IgA) nephropathy. Thus, dysbiosis of the gut microbiota is seen as a crucial contributing factor in NS; however, there is a lack of comprehensive reviews that elucidate the changes in the gut microbiota across different NS conditions and that describe its mechanistic role in the disease. Moreover, serving as an innate regulator of the gut microbiota, traditional Chinese medicine (TCM) has the potential to exert a profound impact on the expression of inflammation-promoting agents, decreasing the levels of endotoxins and uremic toxins. In addition, it strengthens the stability of the intestinal barrier while controlling the metabolic function of the body through its efficient modulation of the gut microbiota. This intricate process yields far-reaching consequences for NS.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1430356/fullnephrotic syndromegut microbiotapathogenesistraditional chinese medicinegutgut-kidney axis |
| spellingShingle | Jing Li Yupei Xu Tianhao Sun Xiaotian Zhang Huimin Liang Wei Lin Hangxing Yu Bo Yang Hongtao Yang Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota Frontiers in Immunology nephrotic syndrome gut microbiota pathogenesis traditional chinese medicine gut gut-kidney axis |
| title | Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota |
| title_full | Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota |
| title_fullStr | Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota |
| title_full_unstemmed | Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota |
| title_short | Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota |
| title_sort | exploration of the pathogenesis of nephrotic syndrome and traditional chinese medicine intervention based on gut microbiota |
| topic | nephrotic syndrome gut microbiota pathogenesis traditional chinese medicine gut gut-kidney axis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1430356/full |
| work_keys_str_mv | AT jingli explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT yupeixu explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT tianhaosun explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT xiaotianzhang explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT huiminliang explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT weilin explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT hangxingyu explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT boyang explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota AT hongtaoyang explorationofthepathogenesisofnephroticsyndromeandtraditionalchinesemedicineinterventionbasedongutmicrobiota |