Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis
Background In patients with idiopathic pulmonary fibrosis (IPF) there is a need to identify biomarkers that 1) are associated with increased risk of adverse outcome and 2) can be used to monitor treatment response or identify disease progression over time. Methods Two consecutive cohorts of patients...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-12-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/6/00570-2024.full |
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| author | Peter M. George Christian Rennison-Jones Giacomo Benvenuti Aliki Sifostratoudaki Finja A. Ottink Wassim Bou-Zeid Roberta E. Ledda Roqia F. Abul Kadir Bushra Johari Claire Fernandez George W.J. Harston Olivier Joly Stephen Gerry Anand Devaraj |
| author_facet | Peter M. George Christian Rennison-Jones Giacomo Benvenuti Aliki Sifostratoudaki Finja A. Ottink Wassim Bou-Zeid Roberta E. Ledda Roqia F. Abul Kadir Bushra Johari Claire Fernandez George W.J. Harston Olivier Joly Stephen Gerry Anand Devaraj |
| author_sort | Peter M. George |
| collection | DOAJ |
| description | Background
In patients with idiopathic pulmonary fibrosis (IPF) there is a need to identify biomarkers that 1) are associated with increased risk of adverse outcome and 2) can be used to monitor treatment response or identify disease progression over time.
Methods
Two consecutive cohorts of patients with IPF were accessed from the Open Source Imaging Consortium database. Automated computed tomography (CT) biomarkers of disease severity incorporating fibrotic and pulmonary vascular features (the reticulovascular score and weighted reticulovascular score (WRVS)) were studied. Relationships between imaging biomarkers, lung function and survival were analysed.
Results
In separate test and validation cohorts, 168 and 176 patients with IPF respectively (median survival 2.6 years) were studied. A threshold of WRVS ≥15% at baseline CT was most strongly associated with transplant-free survival (HR 3.00, 95% CI 1.47–6.10, p=0.002) when adjusted for baseline forced vital capacity (FVC) and age. In patients with 12-month follow-up CT and lung function tests (n=89) an increase in 3% of WRVS (the minimal clinically important difference) was also significantly associated with reduced survival independent of FVC, and outperformed visual evaluation of progressive fibrosis.
Conclusions
WRVS is an automated CT biomarker which can identify patients with IPF at increased risk of progression and is able to reliably capture disease progression over time. |
| format | Article |
| id | doaj-art-90651a3f90114ce8a4112590e0126f9d |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-90651a3f90114ce8a4112590e0126f9d2025-01-14T09:50:22ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-12-0110610.1183/23120541.00570-202400570-2024Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosisPeter M. George0Christian Rennison-Jones1Giacomo Benvenuti2Aliki Sifostratoudaki3Finja A. Ottink4Wassim Bou-Zeid5Roberta E. Ledda6Roqia F. Abul Kadir7Bushra Johari8Claire Fernandez9George W.J. Harston10Olivier Joly11Stephen Gerry12Anand Devaraj13 Department of Interstitial Lung Disease, Royal Brompton Hospital, London, UK Brainomix, Oxford, UK Brainomix, Oxford, UK Brainomix, Oxford, UK Brainomix, Oxford, UK Brainomix, Oxford, UK Department of Medicine and Surgery, University of Parma, Parma, Italy Department of Radiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia Department of Radiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia Brainomix, Oxford, UK Brainomix, Oxford, UK Brainomix, Oxford, UK Centre for Statistics in Medicine, University of Oxford, Oxford, UK National Heart and Lung Institute, Imperial College, London, UK Background In patients with idiopathic pulmonary fibrosis (IPF) there is a need to identify biomarkers that 1) are associated with increased risk of adverse outcome and 2) can be used to monitor treatment response or identify disease progression over time. Methods Two consecutive cohorts of patients with IPF were accessed from the Open Source Imaging Consortium database. Automated computed tomography (CT) biomarkers of disease severity incorporating fibrotic and pulmonary vascular features (the reticulovascular score and weighted reticulovascular score (WRVS)) were studied. Relationships between imaging biomarkers, lung function and survival were analysed. Results In separate test and validation cohorts, 168 and 176 patients with IPF respectively (median survival 2.6 years) were studied. A threshold of WRVS ≥15% at baseline CT was most strongly associated with transplant-free survival (HR 3.00, 95% CI 1.47–6.10, p=0.002) when adjusted for baseline forced vital capacity (FVC) and age. In patients with 12-month follow-up CT and lung function tests (n=89) an increase in 3% of WRVS (the minimal clinically important difference) was also significantly associated with reduced survival independent of FVC, and outperformed visual evaluation of progressive fibrosis. Conclusions WRVS is an automated CT biomarker which can identify patients with IPF at increased risk of progression and is able to reliably capture disease progression over time.http://openres.ersjournals.com/content/10/6/00570-2024.full |
| spellingShingle | Peter M. George Christian Rennison-Jones Giacomo Benvenuti Aliki Sifostratoudaki Finja A. Ottink Wassim Bou-Zeid Roberta E. Ledda Roqia F. Abul Kadir Bushra Johari Claire Fernandez George W.J. Harston Olivier Joly Stephen Gerry Anand Devaraj Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis ERJ Open Research |
| title | Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis |
| title_full | Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis |
| title_fullStr | Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis |
| title_full_unstemmed | Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis |
| title_short | Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis |
| title_sort | evaluation of e lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis |
| url | http://openres.ersjournals.com/content/10/6/00570-2024.full |
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