An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens

An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens

Abstract The increasing incidence of antibiotic resistance and the decline in the discovery of novel antibiotics have resulted in a global health crisis, particularly, for the treatment of infections caused by Gram-negative bacteria, for which therapeutic dead-ends are alarming. Here, we identify an...

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Main Authors: Seav-Ly Tran, Lucie Lebreuilly, Delphine Cormontagne, Samantha Samson, Thu Ba Tô, Marie Stosskopf, Rozenn Dervyn, Anne Grießhammer, Jacobo de la Cuesta-Zuluaga, Lisa Maier, Thierry Naas, Simona Mura, Didier Rognan, Julien Nicolas, Gwenaëlle André, Nalini Ramarao
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58282-8
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