Pulmonary Hemosiderosis in Children with Bronchopulmonary Dysplasia
We describe a possible association between pulmonary hemosiderosis (PH) and a history of bronchopulmonary dysplasia (BPD). Both patients were born at 28-week gestation and presented with PH at ages 22 months and 6 years, respectively. Both initially presented with cough and tachypnea, and bronchoalv...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2014/876195 |
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| author | David Kurahara Marina Morie Maya Yamane Sarah Lam Wallace Matthews Keolamau Yee Kara Yamamoto |
| author_facet | David Kurahara Marina Morie Maya Yamane Sarah Lam Wallace Matthews Keolamau Yee Kara Yamamoto |
| author_sort | David Kurahara |
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| description | We describe a possible association between pulmonary hemosiderosis (PH) and a history of bronchopulmonary dysplasia (BPD). Both patients were born at 28-week gestation and presented with PH at ages 22 months and 6 years, respectively. Both initially presented with cough and tachypnea, and bronchoalveolar lavage showed evidence of hemosiderin-laden macrophages. Initial hemoglobin levels were < 4 g/dL and chest radiographs showed diffuse infiltrates that cleared dramatically within days after initiation of intravenous corticosteroids. In the first case, frank pulmonary blood was observed upon initial intubation, prompting the need for high frequency ventilation, immediate corticosteroids, and antibiotics. The mechanical ventilation wean was made possible by the addition of mycophenolate mofetil (MMF) and hydroxychloroquine. Slow tapering off of medications was accomplished over 6 years. These cases represent a possible correlation between prematurity-associated BPD and PH. We present a review of the literature regarding this possible association. In addition, MMF proved to be life-saving in one of the PH cases, as it has been in pulmonary hemorrhage related to systemic lupus erythematosus. Further studies are warranted to investigate the possible association between PH and prematurity-related BPD, as well as the use of MMF in the treatment of PH. |
| format | Article |
| id | doaj-art-90603112dfce4e67bbcf3ef226dc602c |
| institution | DOAJ |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-90603112dfce4e67bbcf3ef226dc602c2025-08-20T03:20:30ZengWileyCase Reports in Pediatrics2090-68032090-68112014-01-01201410.1155/2014/876195876195Pulmonary Hemosiderosis in Children with Bronchopulmonary DysplasiaDavid Kurahara0Marina Morie1Maya Yamane2Sarah Lam3Wallace Matthews4Keolamau Yee5Kara Yamamoto6Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USAWe describe a possible association between pulmonary hemosiderosis (PH) and a history of bronchopulmonary dysplasia (BPD). Both patients were born at 28-week gestation and presented with PH at ages 22 months and 6 years, respectively. Both initially presented with cough and tachypnea, and bronchoalveolar lavage showed evidence of hemosiderin-laden macrophages. Initial hemoglobin levels were < 4 g/dL and chest radiographs showed diffuse infiltrates that cleared dramatically within days after initiation of intravenous corticosteroids. In the first case, frank pulmonary blood was observed upon initial intubation, prompting the need for high frequency ventilation, immediate corticosteroids, and antibiotics. The mechanical ventilation wean was made possible by the addition of mycophenolate mofetil (MMF) and hydroxychloroquine. Slow tapering off of medications was accomplished over 6 years. These cases represent a possible correlation between prematurity-associated BPD and PH. We present a review of the literature regarding this possible association. In addition, MMF proved to be life-saving in one of the PH cases, as it has been in pulmonary hemorrhage related to systemic lupus erythematosus. Further studies are warranted to investigate the possible association between PH and prematurity-related BPD, as well as the use of MMF in the treatment of PH.http://dx.doi.org/10.1155/2014/876195 |
| spellingShingle | David Kurahara Marina Morie Maya Yamane Sarah Lam Wallace Matthews Keolamau Yee Kara Yamamoto Pulmonary Hemosiderosis in Children with Bronchopulmonary Dysplasia Case Reports in Pediatrics |
| title | Pulmonary Hemosiderosis in Children with Bronchopulmonary Dysplasia |
| title_full | Pulmonary Hemosiderosis in Children with Bronchopulmonary Dysplasia |
| title_fullStr | Pulmonary Hemosiderosis in Children with Bronchopulmonary Dysplasia |
| title_full_unstemmed | Pulmonary Hemosiderosis in Children with Bronchopulmonary Dysplasia |
| title_short | Pulmonary Hemosiderosis in Children with Bronchopulmonary Dysplasia |
| title_sort | pulmonary hemosiderosis in children with bronchopulmonary dysplasia |
| url | http://dx.doi.org/10.1155/2014/876195 |
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