Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids

Benzylisoquinoline alkaloids (BIAs) are a prominent class of plant metabolites with significant pharmaceutical and industrial significance that have garnered substantial attention from researchers worldwide. BIAs exhibit several pharmacological activities and have been used extensively. Examples inc...

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Main Authors: Wanli Zhao, Jihua Liu, Yu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Plant Science
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Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2025.1548471/full
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author Wanli Zhao
Jihua Liu
Yu Chen
author_facet Wanli Zhao
Jihua Liu
Yu Chen
author_sort Wanli Zhao
collection DOAJ
description Benzylisoquinoline alkaloids (BIAs) are a prominent class of plant metabolites with significant pharmaceutical and industrial significance that have garnered substantial attention from researchers worldwide. BIAs exhibit several pharmacological activities and have been used extensively. Examples include analgesics such as morphine, tetrahydropalmatine, antimicrobials such as berberine, and antineoplastic agents including cepharanthine. Most BIAs are derived and isolated from medicinal plants; however, these plants are predominantly wild resources that are scarce. Their high environmental impact, slow growth rate, scarcity of resources, and expensive direct extraction costs pose a significant challenge. Certain BIAs are present in trace amounts in medicinal plants; moreover, they have complex chemical structures and unstable properties. Designing chemical synthesis routes and processes is challenging. Thus, a major obstacle in developing and utilizing these natural products in the pharmaceutical industry lies in their low abundance in nature. Consequently, the limited supply of these molecules fails to meet high research and market demands. In recent years, biosynthesis approaches have emerged as a novel and efficient method to obtain BIAs. In this review, recent progress in the field of enzymes related to the elucidation of biosynthetic pathways and the biosynthesis of BIAs are discussed, and future perspectives for designing viable strategies for their targeted manipulation are presented.
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spelling doaj-art-905613933e7f40d8972fcfaa3f36f8a32025-01-30T06:23:03ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2025-01-011610.3389/fpls.2025.15484711548471Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloidsWanli Zhao0Jihua Liu1Yu Chen2Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Nanjing, ChinaJiangsu Key Laboratory of Traditional Chinese Medicine. (TCM) Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Nanjing, ChinaBenzylisoquinoline alkaloids (BIAs) are a prominent class of plant metabolites with significant pharmaceutical and industrial significance that have garnered substantial attention from researchers worldwide. BIAs exhibit several pharmacological activities and have been used extensively. Examples include analgesics such as morphine, tetrahydropalmatine, antimicrobials such as berberine, and antineoplastic agents including cepharanthine. Most BIAs are derived and isolated from medicinal plants; however, these plants are predominantly wild resources that are scarce. Their high environmental impact, slow growth rate, scarcity of resources, and expensive direct extraction costs pose a significant challenge. Certain BIAs are present in trace amounts in medicinal plants; moreover, they have complex chemical structures and unstable properties. Designing chemical synthesis routes and processes is challenging. Thus, a major obstacle in developing and utilizing these natural products in the pharmaceutical industry lies in their low abundance in nature. Consequently, the limited supply of these molecules fails to meet high research and market demands. In recent years, biosynthesis approaches have emerged as a novel and efficient method to obtain BIAs. In this review, recent progress in the field of enzymes related to the elucidation of biosynthetic pathways and the biosynthesis of BIAs are discussed, and future perspectives for designing viable strategies for their targeted manipulation are presented.https://www.frontiersin.org/articles/10.3389/fpls.2025.1548471/fullbenzylisoquinoline alkaloidsbiosynthesissecondary metabolitebiosynthetic pathwayberberine bridge enzymecytochrome P450
spellingShingle Wanli Zhao
Jihua Liu
Yu Chen
Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
Frontiers in Plant Science
benzylisoquinoline alkaloids
biosynthesis
secondary metabolite
biosynthetic pathway
berberine bridge enzyme
cytochrome P450
title Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
title_full Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
title_fullStr Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
title_full_unstemmed Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
title_short Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
title_sort advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
topic benzylisoquinoline alkaloids
biosynthesis
secondary metabolite
biosynthetic pathway
berberine bridge enzyme
cytochrome P450
url https://www.frontiersin.org/articles/10.3389/fpls.2025.1548471/full
work_keys_str_mv AT wanlizhao advancesinthebiosynthesisofnaturallyoccurringbenzylisoquinolinealkaloids
AT jihualiu advancesinthebiosynthesisofnaturallyoccurringbenzylisoquinolinealkaloids
AT yuchen advancesinthebiosynthesisofnaturallyoccurringbenzylisoquinolinealkaloids