Determination of resilience of a panel of broadly neutralizing mAbs to emerging variants of SARS-CoV-2 generated using reverse genetics

Determination of resilience of a panel of broadly neutralizing mAbs to emerging variants of SARS-CoV-2 generated using reverse genetics

Summary: SARS-CoV-2 continues to evolve, and its emerging variants might escape the immune responses generated by existing vaccines and therapeutic mAbs. Accordingly, rapid analysis of their possible neutralization phenotype is essential and can be facilitated by reverse genetics (RGs) systems to re...

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Bibliographic Details
Main Authors: Madeeha Afzal, Diana Melnyk, Thomas Courty, Lisa Schimanski, Michelle Hill, Stuart Neil, Tiong Kit Tan, William S. James
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Biological sciences
Genetics
Immunology
Immune system evolution
Immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007126
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