Nanotherapies Based on ROS Regulation in Oral Diseases
Abstract Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409087 |
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| _version_ | 1849431054051442688 |
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| author | Xin Luo Yanli Zhang Yuting Zeng Dehong Yang Zhiyan Zhou Ziting Zheng Ping Xiao Xian Ding Qianlin Li Jiaping Chen Qianwen Deng Xincen Zhong Sijie Qiu Wenjuan Yan |
| author_facet | Xin Luo Yanli Zhang Yuting Zeng Dehong Yang Zhiyan Zhou Ziting Zheng Ping Xiao Xian Ding Qianlin Li Jiaping Chen Qianwen Deng Xincen Zhong Sijie Qiu Wenjuan Yan |
| author_sort | Xin Luo |
| collection | DOAJ |
| description | Abstract Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme‐like catalytic properties, unique composition, and intelligent design, ROS‐based nanomaterials have garnered considerable attention in oral nanomedicine. Such nanomaterials have the capacity to influence the spatiotemporal dynamics of ROS within biological systems, guiding the evolution of intra‐ROS to facilitate therapeutic interventions. This paper reviews the latest advancements in the design, functional customization, and oral medical applications of ROS‐based nanomaterials. Through the analysis of the components and designs of various novel nanozymes and ROS‐based nanoplatforms responsive to different stimuli dimensions, it elaborates on their impacts on the dynamic behavior of intra‐ROS and their potential regulatory mechanisms within the body. Furthermore, it discusses the prospects and strategies of nanotherapies based on ROS scavenging and generation in oral diseases, offering alternative insights for the design and development of nanomaterials for treating ROS‐related conditions. |
| format | Article |
| id | doaj-art-904edc43f39043beaf9a09e3cb87ab3f |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-904edc43f39043beaf9a09e3cb87ab3f2025-08-20T03:27:46ZengWileyAdvanced Science2198-38442025-03-01129n/an/a10.1002/advs.202409087Nanotherapies Based on ROS Regulation in Oral DiseasesXin Luo0Yanli Zhang1Yuting Zeng2Dehong Yang3Zhiyan Zhou4Ziting Zheng5Ping Xiao6Xian Ding7Qianlin Li8Jiaping Chen9Qianwen Deng10Xincen Zhong11Sijie Qiu12Wenjuan Yan13Department of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaStomatological Hospital School of Stomatology Southern Medical University Guangzhou 510280 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Orthopedics Spinal Surgery Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaAbstract Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme‐like catalytic properties, unique composition, and intelligent design, ROS‐based nanomaterials have garnered considerable attention in oral nanomedicine. Such nanomaterials have the capacity to influence the spatiotemporal dynamics of ROS within biological systems, guiding the evolution of intra‐ROS to facilitate therapeutic interventions. This paper reviews the latest advancements in the design, functional customization, and oral medical applications of ROS‐based nanomaterials. Through the analysis of the components and designs of various novel nanozymes and ROS‐based nanoplatforms responsive to different stimuli dimensions, it elaborates on their impacts on the dynamic behavior of intra‐ROS and their potential regulatory mechanisms within the body. Furthermore, it discusses the prospects and strategies of nanotherapies based on ROS scavenging and generation in oral diseases, offering alternative insights for the design and development of nanomaterials for treating ROS‐related conditions.https://doi.org/10.1002/advs.202409087endogenous and exogenous stimuli‐responsivenanorobotnanotherapiesnanozymesoral diseasereactive oxygen species (ROS) |
| spellingShingle | Xin Luo Yanli Zhang Yuting Zeng Dehong Yang Zhiyan Zhou Ziting Zheng Ping Xiao Xian Ding Qianlin Li Jiaping Chen Qianwen Deng Xincen Zhong Sijie Qiu Wenjuan Yan Nanotherapies Based on ROS Regulation in Oral Diseases Advanced Science endogenous and exogenous stimuli‐responsive nanorobot nanotherapies nanozymes oral disease reactive oxygen species (ROS) |
| title | Nanotherapies Based on ROS Regulation in Oral Diseases |
| title_full | Nanotherapies Based on ROS Regulation in Oral Diseases |
| title_fullStr | Nanotherapies Based on ROS Regulation in Oral Diseases |
| title_full_unstemmed | Nanotherapies Based on ROS Regulation in Oral Diseases |
| title_short | Nanotherapies Based on ROS Regulation in Oral Diseases |
| title_sort | nanotherapies based on ros regulation in oral diseases |
| topic | endogenous and exogenous stimuli‐responsive nanorobot nanotherapies nanozymes oral disease reactive oxygen species (ROS) |
| url | https://doi.org/10.1002/advs.202409087 |
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