Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease
Background Monocyte to high-density lipoprotein cholesterol ratio (MHR) is considered a novel marker of inflammation. However, whether MHR can predict the risk of diabetic kidney disease (DKD) remains uncertain. Our research aimed to investigate the relationship between MHR and DKD.Methods This was...
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2438846 |
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| author | Wentao Yang Yuanlong Zhong Pengying Zhou Donghui Lu |
| author_facet | Wentao Yang Yuanlong Zhong Pengying Zhou Donghui Lu |
| author_sort | Wentao Yang |
| collection | DOAJ |
| description | Background Monocyte to high-density lipoprotein cholesterol ratio (MHR) is considered a novel marker of inflammation. However, whether MHR can predict the risk of diabetic kidney disease (DKD) remains uncertain. Our research aimed to investigate the relationship between MHR and DKD.Methods This was a cross-sectional retrospective study of 159 participants with type 2 diabetes mellitus. MHR, urinary albumin-to-creatinine ratio (UACR) and other indexes were measured. According to UACR, participants were divided into normal group (UACR < 30 mg/g), moderately increased group (UACR 30-300 mg/g) and severely increased group (UACR > 300 mg/g). The association between MHR and DKD was analyzed.Results MHR was significantly elevated in severely increased albuminuria group (p = 0.029). The prevalence of DKD increased in parallel with the elevation in MHR (p = 0.009). MHR was positively related with DKD in univariate logistic regression analysis (ORs = 11.27, 95%CI 1.26-101.24, p = 0.031). Multivariable logistic regression analysis showed MHR significantly correlated with DKD (ORs = 6.20, 95%CI 1.49-25.84, p = 0.012). Each quartile elevation in MHR was associated with an increased risk of DKD (ORs = 1.90, 95%CI 1.19-3.01, p = 0.007). In subgroup analyses MHR was a risk factor for DKD, particularly in patients with HbA1c <8.0%.Conclusions Our findings suggest that MHR can be used as a marker for the presence and progression of DKD. |
| format | Article |
| id | doaj-art-90499c05186d43dba5949762b0c2a7e0 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-90499c05186d43dba5949762b0c2a7e02025-01-14T06:09:01ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2024.2438846Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney diseaseWentao Yang0Yuanlong Zhong1Pengying Zhou2Donghui Lu3Department of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Nephrology, Shenzhen Luohu People’s Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, ChinaHealth Management Center, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, ChinaDepartment of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaBackground Monocyte to high-density lipoprotein cholesterol ratio (MHR) is considered a novel marker of inflammation. However, whether MHR can predict the risk of diabetic kidney disease (DKD) remains uncertain. Our research aimed to investigate the relationship between MHR and DKD.Methods This was a cross-sectional retrospective study of 159 participants with type 2 diabetes mellitus. MHR, urinary albumin-to-creatinine ratio (UACR) and other indexes were measured. According to UACR, participants were divided into normal group (UACR < 30 mg/g), moderately increased group (UACR 30-300 mg/g) and severely increased group (UACR > 300 mg/g). The association between MHR and DKD was analyzed.Results MHR was significantly elevated in severely increased albuminuria group (p = 0.029). The prevalence of DKD increased in parallel with the elevation in MHR (p = 0.009). MHR was positively related with DKD in univariate logistic regression analysis (ORs = 11.27, 95%CI 1.26-101.24, p = 0.031). Multivariable logistic regression analysis showed MHR significantly correlated with DKD (ORs = 6.20, 95%CI 1.49-25.84, p = 0.012). Each quartile elevation in MHR was associated with an increased risk of DKD (ORs = 1.90, 95%CI 1.19-3.01, p = 0.007). In subgroup analyses MHR was a risk factor for DKD, particularly in patients with HbA1c <8.0%.Conclusions Our findings suggest that MHR can be used as a marker for the presence and progression of DKD.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2438846Diabetic kidney diseasediabetic nephropathymonocyte to high-density lipoprotein cholesterol ratioinflammationdiabetic complications |
| spellingShingle | Wentao Yang Yuanlong Zhong Pengying Zhou Donghui Lu Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease Renal Failure Diabetic kidney disease diabetic nephropathy monocyte to high-density lipoprotein cholesterol ratio inflammation diabetic complications |
| title | Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease |
| title_full | Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease |
| title_fullStr | Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease |
| title_full_unstemmed | Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease |
| title_short | Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease |
| title_sort | monocyte to high density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease |
| topic | Diabetic kidney disease diabetic nephropathy monocyte to high-density lipoprotein cholesterol ratio inflammation diabetic complications |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2438846 |
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