Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes
The immunocompromised population is susceptible to Legionella pneumonia. The diagnosis and treatment of Legionella pneumonia in immunocompromised individuals are challenging clinical endeavors. Previous studies have identified Legionella pneumonia as a potential cause of organizing pneumonia (OP), h...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1510948/full |
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| author | Yingying Chen Sicong Liang Ye Lu Xiangyu Zhou Rui Zheng Yu Chen |
| author_facet | Yingying Chen Sicong Liang Ye Lu Xiangyu Zhou Rui Zheng Yu Chen |
| author_sort | Yingying Chen |
| collection | DOAJ |
| description | The immunocompromised population is susceptible to Legionella pneumonia. The diagnosis and treatment of Legionella pneumonia in immunocompromised individuals are challenging clinical endeavors. Previous studies have identified Legionella pneumonia as a potential cause of organizing pneumonia (OP), however, the association between Legionella pneumonia and OP has not received enough clinical attention. We retrospectively evaluated a case involving Legionella micdadei infection and OP in a patient with myelodysplastic syndrome and concurrent Sweet syndrome. The diagnosis of Legionella micdadei pneumonia was confirmed through various methods: metagenomic next generation sequencing (mNGS), Giemsa-staining and fluorescence in situ hybridization of lung tissue, as well as serum immunofluorescence antibody testing. Histopathological analysis of lung tissue revealed OP. The patient was successfully treated with a combination of antibiotics and low-dose glucocorticoids. In immunocompromised individuals, mNGS was capable of detection non-Legionella pneumophila serogroup 1. The pathological examination is important for identifying secondary OP and provides the evidence for treatment with glucocorticoids. |
| format | Article |
| id | doaj-art-903f4e100a244f6b94ae3e32ecce1099 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-903f4e100a244f6b94ae3e32ecce10992025-08-20T03:00:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15109481510948Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromesYingying Chen0Sicong Liang1Ye Lu2Xiangyu Zhou3Rui Zheng4Yu Chen5Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaThe immunocompromised population is susceptible to Legionella pneumonia. The diagnosis and treatment of Legionella pneumonia in immunocompromised individuals are challenging clinical endeavors. Previous studies have identified Legionella pneumonia as a potential cause of organizing pneumonia (OP), however, the association between Legionella pneumonia and OP has not received enough clinical attention. We retrospectively evaluated a case involving Legionella micdadei infection and OP in a patient with myelodysplastic syndrome and concurrent Sweet syndrome. The diagnosis of Legionella micdadei pneumonia was confirmed through various methods: metagenomic next generation sequencing (mNGS), Giemsa-staining and fluorescence in situ hybridization of lung tissue, as well as serum immunofluorescence antibody testing. Histopathological analysis of lung tissue revealed OP. The patient was successfully treated with a combination of antibiotics and low-dose glucocorticoids. In immunocompromised individuals, mNGS was capable of detection non-Legionella pneumophila serogroup 1. The pathological examination is important for identifying secondary OP and provides the evidence for treatment with glucocorticoids.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1510948/fullLegionella pneumoniaLegionella micdadeiorganizing pneumoniaimmunocompromisedSweet syndrome |
| spellingShingle | Yingying Chen Sicong Liang Ye Lu Xiangyu Zhou Rui Zheng Yu Chen Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes Frontiers in Immunology Legionella pneumonia Legionella micdadei organizing pneumonia immunocompromised Sweet syndrome |
| title | Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes |
| title_full | Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes |
| title_fullStr | Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes |
| title_full_unstemmed | Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes |
| title_short | Case Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes |
| title_sort | case report first report of legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and sweet syndromes |
| topic | Legionella pneumonia Legionella micdadei organizing pneumonia immunocompromised Sweet syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1510948/full |
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