Adaptive PRKAA1 variant in Andeans is associated with improved ventilation and sleep phenotypes

Adaptive PRKAA1 variant in Andeans is associated with improved ventilation and sleep phenotypes

Summary: Highland groups have adapted to the extreme selective pressures of hypoxia at high altitude via alterations in the oxygen-transport cascade. PRKAA1, which encodes the catalytic subunit of the AMP-activated protein kinase (AMPK), is a notable target of natural selection in Andeans and has be...

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Main Authors: Elijah S. Lawrence, Wanjun Gu, Mitchell C. Kong, Santiago Fassardi, Cecilia Anza-Ramirez, Esteban A. Moya, Erica C. Heinrich, James J. Yu, Jeremy E. Orr, Steven Y. Cao, Ana Sanchez-Azofra, Amy M. Cole, James E. Hall, Andrew Lin, Pamala N. DeYoung, Gustavo Vizcardo-Galindo, Jose-Luis Macarlupu, Rómulo Figueroa-Mujíca, Daniela Bermudez, Noemi Corante, Gianpiero L. Cavalleri, Eduardo Gaio, A. Mark Evans, Frank L. Powell, Atul Malhotra, Rany M. Salem, Francisco C. Villafuerte, Tatum S. Simonson
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Health sciences
Medicine
Medical specialty
Precision medicine
atural sciences
Biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011721
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