Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysis
Introduction Recent studies in animal models indicate that recombinant human erythropoietin (rHuEPO) is very effective in enhancing neurological recovery after spinal cord injury (SCI). We described a protocol aimed at evaluating the efficacy of rHuEPO plus methylprednisolone (MP) compared with MP a...
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| Format: | Article |
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e056689.full |
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| author | Yu He Jiaojiao Zhou Yong Zeng Yonggang Zhang Miao Fang Shishu Huang Yueming Song |
| author_facet | Yu He Jiaojiao Zhou Yong Zeng Yonggang Zhang Miao Fang Shishu Huang Yueming Song |
| author_sort | Yu He |
| collection | DOAJ |
| description | Introduction Recent studies in animal models indicate that recombinant human erythropoietin (rHuEPO) is very effective in enhancing neurological recovery after spinal cord injury (SCI). We described a protocol aimed at evaluating the efficacy of rHuEPO plus methylprednisolone (MP) compared with MP alone in improving neurological function of patients with SCI in randomised controlled trials (RCTs).Methods and analysis This study aims to explore the effect of rHuEPO combined with MP on neurological function in patients with SCI through a meta-analysis. To this end, the authors will search eight research databases for data retrieval: MEDLINE, China National Knowledge Infrastructure, Wan Fang, China Biology Medicine dis, Web of Science, PubMed, Cochrane and Embase for RCTs on SCI in any language. The primary outcome will be the American Spinal Injury Association score at the time of follow-up. The secondary outcomes will be the WHOQOL-100 instrument score, neurophysiological state and related factors. Two authors will independently search literature records, scan titles, abstracts and full texts, collect data, and assess materials for risk of bias. Stata V.14.0 will be used for statistical analysis.Ethics and dissemination This research is exempt from ethics approval because the work is carried out on published documents. We will disseminate this protocol in scientific conferences and a peer-reviewed journal.PROSPERO registration number CRD42021260688. |
| format | Article |
| id | doaj-art-902a60d65dee48fab6e9ccee6cd658b3 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-902a60d65dee48fab6e9ccee6cd658b32025-08-20T02:57:17ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2021-056689Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysisYu He0Jiaojiao Zhou1Yong Zeng2Yonggang Zhang3Miao Fang4Shishu Huang5Yueming Song61 Department of Urology, Huazhong University of Science and Technology, Wuhan, China4 Medical Department, Fengtai District Xiluoyuan Community Health Service Center, Beijing, China1 Department of Surgery, West China Hospital, Sichuan University, Chendu, Sichuan Province, ChinaDepartment of Integrated Traditional and Western Medicine, Sichuan University West China Hospital, Chengdu, ChinaDepartment of orthopedics, Chengdu Second People`s Hospital, Chengdu, ChinaDepartment of orthopedics, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of orthopedics, West China Hospital of Sichuan University, Chengdu, ChinaIntroduction Recent studies in animal models indicate that recombinant human erythropoietin (rHuEPO) is very effective in enhancing neurological recovery after spinal cord injury (SCI). We described a protocol aimed at evaluating the efficacy of rHuEPO plus methylprednisolone (MP) compared with MP alone in improving neurological function of patients with SCI in randomised controlled trials (RCTs).Methods and analysis This study aims to explore the effect of rHuEPO combined with MP on neurological function in patients with SCI through a meta-analysis. To this end, the authors will search eight research databases for data retrieval: MEDLINE, China National Knowledge Infrastructure, Wan Fang, China Biology Medicine dis, Web of Science, PubMed, Cochrane and Embase for RCTs on SCI in any language. The primary outcome will be the American Spinal Injury Association score at the time of follow-up. The secondary outcomes will be the WHOQOL-100 instrument score, neurophysiological state and related factors. Two authors will independently search literature records, scan titles, abstracts and full texts, collect data, and assess materials for risk of bias. Stata V.14.0 will be used for statistical analysis.Ethics and dissemination This research is exempt from ethics approval because the work is carried out on published documents. We will disseminate this protocol in scientific conferences and a peer-reviewed journal.PROSPERO registration number CRD42021260688.https://bmjopen.bmj.com/content/12/12/e056689.full |
| spellingShingle | Yu He Jiaojiao Zhou Yong Zeng Yonggang Zhang Miao Fang Shishu Huang Yueming Song Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysis BMJ Open |
| title | Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysis |
| title_full | Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysis |
| title_fullStr | Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysis |
| title_short | Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury：protocol for a systematic review and meta-analysis |
| title_sort | recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/12/12/e056689.full |
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