Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors
<b>Background</b>: The accurate assessment of the glomerular filtration rate (GFR) in potential living kidney donors (PLKDs) is essential for successful transplantation and safeguarding kidney donation practice. Scintigraphy-measured GFR (mGFR) is widely regarded as the clinical referenc...
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MDPI AG
2024-12-01
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| author | Thang Diep Tam Thai Thanh Tran Chuan Khac Hoang Sam Minh Thai |
| author_facet | Thang Diep Tam Thai Thanh Tran Chuan Khac Hoang Sam Minh Thai |
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| description | <b>Background</b>: The accurate assessment of the glomerular filtration rate (GFR) in potential living kidney donors (PLKDs) is essential for successful transplantation and safeguarding kidney donation practice. Scintigraphy-measured GFR (mGFR) is widely regarded as the clinical reference standard. Various estimated GFR (eGFR) equations, such as the Modification of Diet in Renal Disease (MDRD), Cockcroft–Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, have been developed; however, none have been specifically validated for Vietnamese PLKDs. This study aimed to evaluate the accuracy of eGFR formulas compared to mGFR in PLKDs. <b>Methods</b>: This convenience retrospective study analyzed 189 PLKDs at Cho Ray Hospital in Vietnam from January 2014 to December 2020. The eGFR was calculated using various formulas and compared to the mGFR assessed using <sup>99m</sup>Technetium-diethylenetriaminepentaacetic acid. Bias, accuracy, and Bland–Altman plots were used to assess the significance of the eGFR values. <b>Results</b>: The median mGFR was 94.20 mL/min/1.73 m<sup>2</sup> (interquartile range [IQR]: 88.40–100.50). The eGFR values were as follows: 77.52 mL/min/1.73 m<sup>2</sup> (IQR: 70.50–86.33) for CG; 76.14 mL/min/1.73 m<sup>2</sup> (IQR: 68.05–83.37) for MDRD; 106.80 ± 15.24 mL/min/1.73 m<sup>2</sup> for CKD-EPI cystatin C 2012; 96.44 ± 13.40 mL/min/1.73 m<sup>2</sup> for CKD-EPI creatinine cystatin C 2012; 88.74 ± 13.27 mL/min/1.73 m<sup>2</sup> for CKD-EPI creatinine 2021; and 101.32 ± 12.82 mL/min/1.73 m<sup>2</sup> for CKD-EPI creatinine cystatin C 2021. Among these formulas, the CKD-EPI creatinine cystatin C 2012 (P30 = 98.96%) and 2021 (P30 = 97.92%) showed the best consistency with the mGFR, owing to their high accuracy, low bias, and narrow limits of agreement in the Bland–Altman plots. <b>Conclusions</b>: The CKD-EPI equations based on creatinine and cystatin C are reliable tools for donor screening. |
| format | Article |
| id | doaj-art-9027c8a4f5554a36a2d389c395bcb2b5 |
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| publishDate | 2024-12-01 |
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| spelling | doaj-art-9027c8a4f5554a36a2d389c395bcb2b52025-08-20T02:01:19ZengMDPI AGTransplantology2673-39432024-12-015431232010.3390/transplantology5040031Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney DonorsThang Diep0Tam Thai Thanh Tran1Chuan Khac Hoang2Sam Minh Thai3Faculty of Medicine, Van Lang University, 69/68 Dang Thuy Tram Street, Ward 13, Binh Thanh District, Ho Chi Minh City 700000, VietnamDepartment of Physiology, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City 900000, VietnamDepartment of Urology, Cho Ray Hospital, 201B Nguyen Chi Thanh Street, District 5, Ho Chi Minh City 700000, VietnamDepartment of Urology, Cho Ray Hospital, 201B Nguyen Chi Thanh Street, District 5, Ho Chi Minh City 700000, Vietnam<b>Background</b>: The accurate assessment of the glomerular filtration rate (GFR) in potential living kidney donors (PLKDs) is essential for successful transplantation and safeguarding kidney donation practice. Scintigraphy-measured GFR (mGFR) is widely regarded as the clinical reference standard. Various estimated GFR (eGFR) equations, such as the Modification of Diet in Renal Disease (MDRD), Cockcroft–Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, have been developed; however, none have been specifically validated for Vietnamese PLKDs. This study aimed to evaluate the accuracy of eGFR formulas compared to mGFR in PLKDs. <b>Methods</b>: This convenience retrospective study analyzed 189 PLKDs at Cho Ray Hospital in Vietnam from January 2014 to December 2020. The eGFR was calculated using various formulas and compared to the mGFR assessed using <sup>99m</sup>Technetium-diethylenetriaminepentaacetic acid. Bias, accuracy, and Bland–Altman plots were used to assess the significance of the eGFR values. <b>Results</b>: The median mGFR was 94.20 mL/min/1.73 m<sup>2</sup> (interquartile range [IQR]: 88.40–100.50). The eGFR values were as follows: 77.52 mL/min/1.73 m<sup>2</sup> (IQR: 70.50–86.33) for CG; 76.14 mL/min/1.73 m<sup>2</sup> (IQR: 68.05–83.37) for MDRD; 106.80 ± 15.24 mL/min/1.73 m<sup>2</sup> for CKD-EPI cystatin C 2012; 96.44 ± 13.40 mL/min/1.73 m<sup>2</sup> for CKD-EPI creatinine cystatin C 2012; 88.74 ± 13.27 mL/min/1.73 m<sup>2</sup> for CKD-EPI creatinine 2021; and 101.32 ± 12.82 mL/min/1.73 m<sup>2</sup> for CKD-EPI creatinine cystatin C 2021. Among these formulas, the CKD-EPI creatinine cystatin C 2012 (P30 = 98.96%) and 2021 (P30 = 97.92%) showed the best consistency with the mGFR, owing to their high accuracy, low bias, and narrow limits of agreement in the Bland–Altman plots. <b>Conclusions</b>: The CKD-EPI equations based on creatinine and cystatin C are reliable tools for donor screening.https://www.mdpi.com/2673-3943/5/4/31glomerular filtration ratecreatininecystatin Ckidney donationliving donorsVietnam |
| spellingShingle | Thang Diep Tam Thai Thanh Tran Chuan Khac Hoang Sam Minh Thai Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors Transplantology glomerular filtration rate creatinine cystatin C kidney donation living donors Vietnam |
| title | Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors |
| title_full | Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors |
| title_fullStr | Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors |
| title_full_unstemmed | Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors |
| title_short | Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors |
| title_sort | accuracy of estimated glomerular filtration rate equations in potential vietnamese living kidney donors |
| topic | glomerular filtration rate creatinine cystatin C kidney donation living donors Vietnam |
| url | https://www.mdpi.com/2673-3943/5/4/31 |
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