Dual-ended readout TOF-DOI PET detectors based on 3.2 mm and 1.6 mm pitch LYSO arrays
Abstract Background The image quality of positron emission tomography (PET) can be significantly enhanced by using time-of-flight (TOF) and depth-of-interaction (DOI) information. PET detectors are pivotal in determining the TOF and DOI capabilities of PET scanners. Methods This study developed and...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-05-01
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| Series: | EJNMMI Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40658-025-00759-y |
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| Summary: | Abstract Background The image quality of positron emission tomography (PET) can be significantly enhanced by using time-of-flight (TOF) and depth-of-interaction (DOI) information. PET detectors are pivotal in determining the TOF and DOI capabilities of PET scanners. Methods This study developed and evaluated TOF-DOI PET detectors based on the dual-ended readout method and lutetium-yttrium oxyorthosilicate (LYSO) arrays with two different pitches and reflector configurations. Specifically, the performance of detectors based on three types of LYSO arrays with 20 mm thickness, 8 × 8 arrays with a 3.2 mm pitch, 16 × 16 arrays with a 1.6 mm pitch and normal reflectors, and 16 × 16 arrays with a 1.6 mm pitch and partial short reflectors, were assessed. Hamamatsu S14161-3050-08 silicon photomultiplier arrays were used as the photodetectors, and PETsys TOFPET2 was used as the readout electronics. Results The flood histograms showed that all crystals in the three types of LYSO arrays were clearly resolved. The detectors based on the 8 × 8 LYSO arrays provided a coincidence timing resolution (CTR) of 207 ± 5 ps and a DOI resolution of 3.9 ± 0.6 mm. The detectors based on the 16 × 16 LYSO arrays with normal reflectors provided a CTR of 218 ± 7 ps and a DOI resolution of 2.6 ± 0.2 mm. In comparison, the detector based on the 16 × 16 LYSO arrays with partial short reflectors provided a CTR of 228 ± 11 ps and a DOI resolution of 2.9 ± 0.3 mm, and superior crystal resolvability compared to the detectors based on the 16 × 16 LYSO arrays with normal reflectors. Conclusion These detectors are promising candidates for developing whole-body and brain PET scanners, offering effective sensitivity and uniform spatial resolution improvements across the field-of-view. |
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| ISSN: | 2197-7364 |