CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment
Cognitive impairment (CI) continues to be a concern for people living with HIV-1 (PLWH) in the era of antiretroviral therapy (ART), yet the underlying mechanisms remain unclear. We aimed to elucidate the structural and functional brain alterations and peripheral immune profile of PLWH with CI, as we...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000437 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825199588309467136 |
|---|---|
| author | Xin Zhang Zhen Li Jiahao Ji Yundong Ma Guangqiang Sun Xue Chen Ling Zhang Tong Zhang Yulin Zhang Yang Zhang |
| author_facet | Xin Zhang Zhen Li Jiahao Ji Yundong Ma Guangqiang Sun Xue Chen Ling Zhang Tong Zhang Yulin Zhang Yang Zhang |
| author_sort | Xin Zhang |
| collection | DOAJ |
| description | Cognitive impairment (CI) continues to be a concern for people living with HIV-1 (PLWH) in the era of antiretroviral therapy (ART), yet the underlying mechanisms remain unclear. We aimed to elucidate the structural and functional brain alterations and peripheral immune profile of PLWH with CI, as well as the correlation between them. PLWH were divided into CI (n = 30) and cognitive normal (CN, n = 59) groups based on the Montreal Cognitive Assessment, and underwent multi-modal magnetic resonance imaging. Mass cytometry was utilized to profile immune cells, while the liquid chip technique was employed to measure plasma levels of cytokines and chemokines. Spearman correlation analyses were conducted for correlation analysis. Here, we found that the gray matter volume in left supramarginal gyrus was reduced, and the ReHo in the right middle frontal gyrus and the functional connectivity between right middle frontal gyrus and left postcentral gyrus were enhanced in CI group compared to CN group. Additionally, the frequencies of naïve CD8+T cells (Tn) and CD31lowCD8+ Tn were significantly correlated with gray matter volume in the left supramarginal gyrus. The amplitude of low frequency fluctuations in a specific brain region of frontal-middle lobe was negatively correlated with the frequencies of non-classical monocytes (nCM) and their subpopulations (CCR2lownCM, CD57lownCM and CD127+nCM), and positively associated with the plasma interleukin 25 and transforming growth factor-α levels. These findings suggest the association between peripheral immunity and the brain abnormalities in PLWH, highlighting a potential role of the immune-brain-cognition axis in the pathogenesis of CI in Chinese PLWH. |
| format | Article |
| id | doaj-art-901f1ad727f143e291a6f2039f02db22 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-901f1ad727f143e291a6f2039f02db222025-02-08T04:59:28ZengElsevierBrain Research Bulletin1873-27472025-03-01222111231CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairmentXin Zhang0Zhen Li1Jiahao Ji2Yundong Ma3Guangqiang Sun4Xue Chen5Ling Zhang6Tong Zhang7Yulin Zhang8Yang Zhang9Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 100069, China; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 100069, China; Beijing Institute of Hepatology, 100069, ChinaBeijing Key Laboratory for HIV/AIDS Research, Beijing Youan Hospital, Capital Medical University, 100069, ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 100069, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, 100088, ChinaCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 100069, ChinaCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 100069, ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 100069, ChinaCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing Youan Hospital, Capital Medical University, 100069, China; Corresponding author at: Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 100069, China.Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 100069, China; Beijing Institute of Hepatology, 100069, China; Corresponding author at: Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 100069, China.Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 100069, China; Correspondence to: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 100069, China.Cognitive impairment (CI) continues to be a concern for people living with HIV-1 (PLWH) in the era of antiretroviral therapy (ART), yet the underlying mechanisms remain unclear. We aimed to elucidate the structural and functional brain alterations and peripheral immune profile of PLWH with CI, as well as the correlation between them. PLWH were divided into CI (n = 30) and cognitive normal (CN, n = 59) groups based on the Montreal Cognitive Assessment, and underwent multi-modal magnetic resonance imaging. Mass cytometry was utilized to profile immune cells, while the liquid chip technique was employed to measure plasma levels of cytokines and chemokines. Spearman correlation analyses were conducted for correlation analysis. Here, we found that the gray matter volume in left supramarginal gyrus was reduced, and the ReHo in the right middle frontal gyrus and the functional connectivity between right middle frontal gyrus and left postcentral gyrus were enhanced in CI group compared to CN group. Additionally, the frequencies of naïve CD8+T cells (Tn) and CD31lowCD8+ Tn were significantly correlated with gray matter volume in the left supramarginal gyrus. The amplitude of low frequency fluctuations in a specific brain region of frontal-middle lobe was negatively correlated with the frequencies of non-classical monocytes (nCM) and their subpopulations (CCR2lownCM, CD57lownCM and CD127+nCM), and positively associated with the plasma interleukin 25 and transforming growth factor-α levels. These findings suggest the association between peripheral immunity and the brain abnormalities in PLWH, highlighting a potential role of the immune-brain-cognition axis in the pathogenesis of CI in Chinese PLWH.http://www.sciencedirect.com/science/article/pii/S0361923025000437Human immunodeficiency virus-1Cognitive impairmentMulti-modal magnetic resonancePeripheral immunityCytokinesChemokines |
| spellingShingle | Xin Zhang Zhen Li Jiahao Ji Yundong Ma Guangqiang Sun Xue Chen Ling Zhang Tong Zhang Yulin Zhang Yang Zhang CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment Brain Research Bulletin Human immunodeficiency virus-1 Cognitive impairment Multi-modal magnetic resonance Peripheral immunity Cytokines Chemokines |
| title | CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment |
| title_full | CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment |
| title_fullStr | CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment |
| title_full_unstemmed | CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment |
| title_short | CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment |
| title_sort | cd8 t cells and monocytes were associated with brain alterations in human immunodeficiency virus infected individuals with cognitive impairment |
| topic | Human immunodeficiency virus-1 Cognitive impairment Multi-modal magnetic resonance Peripheral immunity Cytokines Chemokines |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000437 |
| work_keys_str_mv | AT xinzhang cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT zhenli cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT jiahaoji cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT yundongma cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT guangqiangsun cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT xuechen cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT lingzhang cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT tongzhang cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT yulinzhang cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment AT yangzhang cd8tcellsandmonocyteswereassociatedwithbrainalterationsinhumanimmunodeficiencyvirusinfectedindividualswithcognitiveimpairment |